由源自脊髓灰质炎病毒RNA的序列指导的真核生物mRNA的内部翻译起始。
Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA.
作者信息
Pelletier J, Sonenberg N
机构信息
Department of Biochemistry, McGill University, Montreal, Quebec, Canada.
出版信息
Nature. 1988 Jul 28;334(6180):320-5. doi: 10.1038/334320a0.
DOI:10.1038/334320a0
PMID:2839775
Abstract
Poliovirus RNA is naturally uncapped, therefore its translation must proceed via a cap-independent mechanism. Translation initiation on poliovirus RNA occurs by binding of ribosomes to an internal sequence within the 5' noncoding region. This novel mechanism of initiation may explain the disparate translation of several other eukaryotic messenger RNAs.
摘要
脊髓灰质炎病毒核糖核酸天然无帽结构，因此其翻译必须通过不依赖帽结构的机制进行。脊髓灰质炎病毒核糖核酸的翻译起始是通过核糖体与5'非编码区内的一个内部序列结合而发生的。这种新颖的起始机制可能解释了其他几种真核生物信使核糖核酸的不同翻译情况。
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