Bai Siyi, Chen Xun, Hu Xinwei, Deng Yuanfu, Jiang Huanfeng, Zeng Wei
Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, China.
Org Biomol Chem. 2017 May 3;15(17):3638-3647. doi: 10.1039/c7ob00367f.
An Ir(iii)-catalyzed relay aryl C-H bond carbenoid insertion cascade of N-aryl-2-pyridinamines with diazo Meldrum's acid has been developed. This method provides an efficient approach to multifunctionalized 1,3-dihydroindol-2-ones with a broad range of functional group tolerance. Furthermore, this protocol could be applied for the concise synthesis of bioactive hematopoietic growth factor analogues.
已开发出一种铱（III）催化的N-芳基-2-吡啶胺与重氮丙二酸亚异丙酯的接力芳基C-H键类卡宾插入串联反应。该方法为具有广泛官能团耐受性的多官能化1,3-二氢吲哚-2-酮提供了一种有效途径。此外，该方案可用于生物活性造血生长因子类似物的简洁合成。
