Transition metal-catalyzed cross-coupling reactions of -aryl-2-aminopyridines.

Due to the presence of the pyridyl directing group, -aryl-2-aminopyridines can quickly form stable complexes with metals, leading to cyclization and functionalization reactions. A large number of N-heterocycles and nitrogen-based molecules can be easily constructed this direct and atom-economical cross-coupling strategy. In this review, we have highlighted the transformations of -aryl-2-aminopyridines in the presence of various transition metal catalysts, such as palladium, rhodium, iridium, ruthenium, cobalt and copper.