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本文引用的文献

1
Recent advances in understanding and treating ARDS.急性呼吸窘迫综合征（ARDS）的认识与治疗新进展
F1000Res. 2016 Apr 22;5. doi: 10.12688/f1000research.7646.1. eCollection 2016.
2
Levels of Soluble Receptor for Advanced Glycation End Products in Bronchoalveolar Lavage Fluid in Patients with Various Inflammatory Lung Diseases.各种炎症性肺病患者支气管肺泡灌洗液中晚期糖基化终末产物可溶性受体水平
Clin Med Insights Circ Respir Pulm Med. 2016 Apr 28;9(Suppl 1):147-54. doi: 10.4137/CCRPM.S23326. eCollection 2015.
3
Elevated Plasma Levels of sRAGE Are Associated With Nonfocal CT-Based Lung Imaging in Patients With ARDS: A Prospective Multicenter Study.sRAGE血浆水平升高与急性呼吸窘迫综合征患者基于CT的非局灶性肺部成像相关：一项前瞻性多中心研究
Chest. 2016 Nov;150(5):998-1007. doi: 10.1016/j.chest.2016.03.016. Epub 2016 Mar 23.
4
A Pathophysiologic Approach to Biomarkers in Acute Respiratory Distress Syndrome.急性呼吸窘迫综合征生物标志物的病理生理学研究方法
Dis Markers. 2016;2016:3501373. doi: 10.1155/2016/3501373. Epub 2016 Feb 11.
5
Net alveolar fluid clearance is associated with lung morphology phenotypes in acute respiratory distress syndrome.肺胞腔净液清除与急性呼吸窘迫综合征的肺形态表型有关。
Anaesth Crit Care Pain Med. 2016 Apr;35(2):81-6. doi: 10.1016/j.accpm.2015.11.006. Epub 2016 Feb 27.
6
Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries.全球 50 个国家重症监护病房急性呼吸窘迫综合征患者的流行病学、治疗模式和死亡率。
JAMA. 2016 Feb 23;315(8):788-800. doi: 10.1001/jama.2016.0291.
7
Soluble Forms and Ligands of the Receptor for Advanced Glycation End-Products in Patients with Acute Respiratory Distress Syndrome: An Observational Prospective Study.急性呼吸窘迫综合征患者晚期糖基化终产物受体的可溶性形式和配体：一项前瞻性观察研究。
PLoS One. 2015 Aug 14;10(8):e0135857. doi: 10.1371/journal.pone.0135857. eCollection 2015.
8
Distinct molecular phenotypes of direct vs indirect ARDS in single-center and multicenter studies.单中心和多中心研究中直接与间接急性呼吸窘迫综合征的不同分子表型。
Chest. 2015 Jun;147(6):1539-1548. doi: 10.1378/chest.14-2454.
9
Soluble Receptor for Advanced Glycation End-Products Predicts Impaired Alveolar Fluid Clearance in Acute Respiratory Distress Syndrome.可溶性晚期糖基化终产物受体预测急性呼吸窘迫综合征肺泡液体清除功能受损。
Am J Respir Crit Care Med. 2015 Jul 15;192(2):191-9. doi: 10.1164/rccm.201501-0020OC.
10
Effects of a recruitment maneuver on plasma levels of soluble RAGE in patients with diffuse acute respiratory distress syndrome: a prospective randomized crossover study.招募手法对弥漫性急性呼吸窘迫综合征患者血浆可溶性 RAGE 水平的影响：一项前瞻性随机交叉研究。
Intensive Care Med. 2015 May;41(5):846-55. doi: 10.1007/s00134-015-3726-0. Epub 2015 Mar 20.

近期对潜在急性呼吸窘迫综合征的见解。

Recent insight into potential acute respiratory distress syndrome.

作者信息

Amin Zulkifli, Rahmawati Fitriana N

机构信息

Internal Medicine Department, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia. E-mail.

出版信息

Saudi Med J. 2017 Apr;38(4):344-349. doi: 10.15537/smj.2017.4.15843.

DOI:10.15537/smj.2017.4.15843
PMID:28397939
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5447185/
Abstract

Acute respiratory distress syndrome (ARDS) is an acute inflammatory lung injury, characterized by increased pulmonary capillary endothelial cells and alveolar epithelial cells permeability leading to respiratory failure in the absence of cardiac failure. Despite recent advances in treatments, the overall mortality because of ARDS remains high. Biomarkers may help to diagnose, predict the severity, development, and outcome of ARDS in order to improve patient care and decrease morbidity and mortality. This review will focus on soluble receptor for advanced glycation end-products, soluble tumor necrosis factor-receptor 1, Interluken-6 (IL-6), IL-8, and plasminogen activator inhibitor-1, which have a greater potential based on recent studies.

摘要

急性呼吸窘迫综合征（ARDS）是一种急性炎症性肺损伤，其特征是肺毛细血管内皮细胞和肺泡上皮细胞通透性增加，在无心力衰竭的情况下导致呼吸衰竭。尽管近年来治疗取得了进展，但ARDS导致的总体死亡率仍然很高。生物标志物可能有助于诊断、预测ARDS的严重程度、发展及预后，以改善患者护理并降低发病率和死亡率。本综述将聚焦于晚期糖基化终产物可溶性受体、可溶性肿瘤坏死因子受体1、白细胞介素-6（IL-6）、IL-8和纤溶酶原激活物抑制剂-1，基于近期研究，它们具有更大的潜力。