D'Orazio Giovanni, Kakava Rusudan, Volonterio Alessandro, Fanali Salvatore, Chankvetadze Bezhan
Institute of Chemical Methodologies, Italian National Research Council (CNR), Monterotondo, Italy.
Institute of Physical and Analytical Chemistry, School of Exact and Natural Sciences, Tbilisi State University, Tbilisi, Georgia.
Electrophoresis. 2017 Aug;38(15):1932-1938. doi: 10.1002/elps.201700126. Epub 2017 May 10.
In the present study, an attempt was made to achieve separation of enantiomers within a minute in nano-LC and CEC. In order to achieve this goal several parameters were optimized from the viewpoint of the property of chiral analytes, concentration of the chiral selector in the packing material, capillary dimensions, and separation mode. The enantiomers of several of the applied chiral sulfoxides could be resolved with the analysis time <1 min. Some instrumental obstacles hindering further reduction of analysis time are also highlighted.
在本研究中，尝试在纳升液相色谱和毛细管电色谱中在一分钟内实现对映体的分离。为了实现这一目标，从手性分析物的性质、填充材料中手性选择剂的浓度、毛细管尺寸和分离模式等方面对几个参数进行了优化。几种应用的手性亚砜的对映体可以在分析时间<1分钟的情况下得到分离。还强调了阻碍进一步缩短分析时间的一些仪器障碍。
