Cirelli Chiara
Department of Psychiatry, University of Wisconsin, Madison, WI 53719, USA.
Curr Opin Neurobiol. 2017 Jun;44:72-79. doi: 10.1016/j.conb.2017.03.016. Epub 2017 Apr 8.
The synaptic homeostasis hypothesis (SHY) states that wake brings about a net overall increase in synaptic strength in many brain circuits that needs to be renormalized by sleep. I will review recent studies that were either specifically designed to test SHY or were interpreted accordingly, including several experiments that focused on changes in neuronal firing rates. I will emphasize that central to SHY is the idea that what is being regulated across the sleep/wake cycle is synaptic strength, not firing rate, and firing rate taken in isolation is not necessarily an adequate proxy for synaptic strength.
突触稳态假说(SHY)指出,清醒状态会导致许多脑回路中的突触强度总体净增加,而这种增加需要通过睡眠来重新归一化。我将回顾最近专门设计用于测试SHY或据此进行解释的研究,包括几项关注神经元放电率变化的实验。我将强调,SHY的核心观点是,在睡眠/清醒周期中被调节的是突触强度,而不是放电率,单独的放电率不一定是突触强度的充分指标。