Bodurtha J, Adler S P, Nance W E
Children's Medical Center, Department of Pediatrics, Medical College of Virginia, Richmond.
Am J Epidemiol. 1988 Aug;128(2):268-76. doi: 10.1093/oxfordjournals.aje.a114967.
To determine the importance of intrafamilial transmission of cytomegalovirus and herpes simplex virus (types 1 and 2), the authors investigated the presence of immunoglobulin G antibody to one or both of these viruses in the sera collected between 1976 and 1985 from 1,115 members of 301 kinships from Virginia consisting either of juvenile twins and their parents or of adult twins, their spouses, and offspring. The sample included 486 children and 629 adults, aged 1-68 years. Among the 125 couples in whom the wives were seropositive, 78 (62%) of the husbands were found to be seropositive. Among 77 couples in whom the wives were seronegative, only 32 (42%) of the husbands were seropositive (p less than 0.01). Of 105 couples in whom the wives were seropositive for herpes simplex virus, 81 (77%) husbands were seropositive compared with 20 (47%) of 43 husbands with herpes simplex virus-seronegative wives (p less than 0.001). In families with cytomegalovirus-seropositive mothers, 54 (25%) of 213 children were seropositive for cytomegalovirus compared with 13 (8%) of 168 children in families with seronegative mothers (p less than 0.001). Childhood cytomegalovirus infections showed no association with infection in the father. In contrast, among families in which both parents were seropositive for herpes simplex virus, 48 (31%) of 156 children were seropositive compared with only two (4%) of 48 children without herpes simplex virus-seropositive parents (p less than 0.001). Among all siblings, there were strong associations for both herpes simplex virus and cytomegalovirus infections. These data are consistent with the venereal transmission of cytomegalovirus in married couples, provide evidence for the intrafamilial spread of herpes simplex virus, and confirm the importance of the maternal-child transmission of cytomegalovirus.
为了确定巨细胞病毒和单纯疱疹病毒（1型和2型）的家庭内传播的重要性，作者调查了1976年至1985年间从弗吉尼亚州301个亲属关系的1115名成员中采集的血清中针对这两种病毒中一种或两种的免疫球蛋白G抗体的存在情况。这些亲属关系包括青少年双胞胎及其父母，或成年双胞胎、他们的配偶和后代。样本包括486名儿童和629名成年人，年龄在1至68岁之间。在125对妻子血清学阳性的夫妻中，发现78名（62%）丈夫血清学阳性。在77对妻子血清学阴性的夫妻中，只有32名（42%）丈夫血清学阳性（p小于0.01）。在105对妻子单纯疱疹病毒血清学阳性的夫妻中，81名（77%）丈夫血清学阳性，而在43对妻子单纯疱疹病毒血清学阴性的夫妻中，20名（47%）丈夫血清学阳性（p小于0.001）。在母亲巨细胞病毒血清学阳性的家庭中，213名儿童中有54名（25%）巨细胞病毒血清学阳性，而在母亲血清学阴性的家庭中，168名儿童中有13名（8%）巨细胞病毒血清学阳性（p小于0.001）。儿童期巨细胞病毒感染与父亲的感染没有关联。相比之下，在父母双方单纯疱疹病毒血清学均阳性的家庭中，156名儿童中有48名（31%）血清学阳性，而在父母无单纯疱疹病毒血清学阳性的48名儿童中只有2名（4%）血清学阳性（p小于0.001）。在所有兄弟姐妹中，单纯疱疹病毒和巨细胞病毒感染都有很强的关联性。这些数据与已婚夫妻中巨细胞病毒的性传播一致，为单纯疱疹病毒的家庭内传播提供了证据，并证实了巨细胞病毒母婴传播的重要性。
