Cheng Hung-Yuan, Elbers Roy G, Higgins Julian P T, Taylor Abigail, MacArthur Georgina J, McGuinness Luke, Dawson Sarah, López-López José A, Cowlishaw Sean, Hickman Matthew, Kessler David
School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK.
National Institute for Health Research (NIHR) Health Protection Research Unit (HPRU) on Evaluation of Interventions, University of Bristol, Bristol, UK.
Syst Rev. 2017 Apr 11;6(1):77. doi: 10.1186/s13643-017-0462-2.
Alcohol dependence is common and serious cause of social and physical harm. However, the optimal management of those with moderate and severe alcohol dependence in primary and community care after detoxification remains unclear. The aim of this review is to evaluate the effectiveness of interventions for maintaining abstinence in people with alcohol dependence following detoxification.
We will systematically search electronic databases and clinical trial registries for randomized controlled trials (RCTs) examining the effectiveness of pharmacological and/or psychosocial interventions for maintaining abstinence in recently detoxified, alcohol-dependent adults. The searches will be complemented by checking references and citations from included studies and other relevant systematic reviews. No limitation on language, year, or publication status will be applied. RCTs will be selected using prespecified criteria. Descriptive information, study characteristics, and results of eligible RCTs will be extracted. A revised version of the Cochrane Risk of Bias tool (RoB 2.0) will be used to assess the risk of bias in eligible RCTs. Results will be synthesized and analyzed using network meta-analysis (NMA). Overall strength of the evidence and publication bias will be evaluated. Subgroup and sensitivity analysis will also be performed.
This network meta-analysis aims to appraise and summarize the total evidence of therapeutic interventions for alcohol-dependent patients that require support for detoxification and can be treated in the community. The evidence will determine which combination of interventions are most promising for current practice and further investigation.
PROSPERO CRD42016049779.
酒精依赖是常见且严重的社会和身体危害原因。然而，在初级和社区护理中，对中度和重度酒精依赖者脱毒后的最佳管理仍不明确。本综述的目的是评估干预措施对酒精依赖者脱毒后保持戒酒的有效性。
我们将系统检索电子数据库和临床试验注册库，以查找随机对照试验（RCT），这些试验检验了药物和/或心理社会干预措施对近期脱毒的酒精依赖成年患者保持戒酒的有效性。检索将通过检查纳入研究的参考文献和引用以及其他相关系统评价来补充。不设语言、年份或出版状态限制。将使用预先设定的标准选择RCT。将提取符合条件的RCT的描述性信息、研究特征和结果。将使用Cochrane偏倚风险工具（RoB 2.0）的修订版来评估符合条件的RCT中的偏倚风险。结果将使用网络荟萃分析（NMA）进行综合和分析。将评估证据的总体强度和发表偏倚。还将进行亚组分析和敏感性分析。
本网络荟萃分析旨在评估和总结对需要脱毒支持且可在社区治疗的酒精依赖患者的治疗干预的全部证据。该证据将确定哪些干预措施组合对当前实践和进一步研究最有前景。
PROSPERO CRD42016049779。
