Shi Meng-Meng, Shi Chang-He, Xu Yu-Ming
Department of Neurology, The first affiliated Hospital, Zhengzhou University Zhengzhou, China.
Front Cell Neurosci. 2017 Mar 28;11:81. doi: 10.3389/fncel.2017.00081. eCollection 2017.
Parkinson's disease (PD) is a progressive movement disorder with multiple non-motor symptoms. Although family genetic mutations only account for a small proportion of the cases, these mutations have provided several lines of evidence for the pathogenesis of PD, such as mitochondrial dysfunction, protein misfolding and aggregation, and the impaired autophagy-lysosome system. Recently, vesicle trafficking defect has emerged as a potential pathogenesis underlying this disease. Rab GTPases, serving as the core regulators of cellular membrane dynamics, may play an important role in the molecular pathway of PD through the complex interplay with numerous factors and PD-related genes. This might shed new light on the potential therapeutic strategies. In this review, we emphasize the important role of Rab GTPases in vesicle trafficking and summarize the interactions between Rab GTPases and different PD-related genes.
帕金森病（PD）是一种具有多种非运动症状的进行性运动障碍。尽管家族基因突变仅占病例的一小部分，但这些突变已为PD的发病机制提供了多条证据，如线粒体功能障碍、蛋白质错误折叠和聚集以及自噬-溶酶体系统受损。最近，囊泡运输缺陷已成为该疾病潜在的发病机制。Rab GTPases作为细胞膜动力学的核心调节因子，可能通过与众多因子和PD相关基因的复杂相互作用，在PD的分子途径中发挥重要作用。这可能为潜在的治疗策略提供新的思路。在本综述中，我们强调Rab GTPases在囊泡运输中的重要作用，并总结Rab GTPases与不同PD相关基因之间的相互作用。
