Behnamfar Fariba, Rouholamin Safoura, Esteki Mahboubeh
Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Biomed Res. 2017 Mar 7;6:29. doi: 10.4103/2277-9175.201686. eCollection 2017.
Placental site throphoblastic tumor (PSTT) is a rare manifestation of gestational trophoblastic neoplasia that may complicate any type of pregnancy. The disease is unique from other type, and is defined by slow growth, low human chorionic gonadotropin (hCG) serum levels, the late-onset metastatic potential, and most significantly, insensitivity to chemotherapy. We describe a case of a 31-year-old woman with prolonged amenorrhea and slightly elevated serum beta hCG (βhCG) level, referred for termination of abnormal pregnancy. During curettage, necrotic tissue was removed and severs vaginal bleeding was controlled with medical therapy. Histology examination showed neoplastic intermediate trophoblastic cells with invasion to the vessel wall compatible with PSTT. After that, hysterectomy was down and serum βhCG declined to undetectable level 2 weeks after surgery and was followed for 2 years without complication.
胎盘部位滋养细胞肿瘤（PSTT）是妊娠滋养细胞肿瘤的一种罕见表现形式，可使任何类型的妊娠复杂化。该疾病与其他类型不同，其特点是生长缓慢、血清人绒毛膜促性腺激素（hCG）水平低、晚期转移潜能，最重要的是对化疗不敏感。我们描述了一例31岁女性病例，该患者闭经时间延长，血清β人绒毛膜促性腺激素（βhCG）水平略有升高，因异常妊娠终止前来就诊。刮宫术中，清除了坏死组织，并通过药物治疗控制了严重的阴道出血。组织学检查显示肿瘤中间滋养细胞浸润血管壁，符合PSTT。此后，进行了子宫切除术，术后2周血清βhCG降至无法检测的水平，并随访2年无并发症。
