Nagamine Kimberly, Iwasaki Sophia, Shimizu David, Tauchi-Nishi Pamela, Terada Keith
Department of Obstetrics and Gynecology, University of Hawaii, Kapiolani Medical Center for Women and Children, 1319 Punahou Street, Room 824, Honolulu, HI 96826, United States.
Department of Pathology, The Queen's Medical Center, 1301 Punchbowl Street, Honolulu, HI 96813, United States.
Gynecol Oncol Rep. 2017 Jul 12;21:86-90. doi: 10.1016/j.gore.2017.07.003. eCollection 2017 Aug.
Placental site trophoblastic tumor (PSTT) is a rare form of gestational trophoblastic neoplasia (GTN). It most commonly occurs after a delivery but may arise after any type of pregnancy. PSTT arises after neoplastic transformation of intermediate trophoblastic cells. The most commonly reported symptoms are abnormal bleeding or amenorrhea. Due to the rarity of this disease, evidence on prognostic factors as well as optimal treatment is limited. While treatment for early-stage disease is usually limited to surgery, multimodal treatment with chemotherapy and surgery may be important for metastatic disease. Metastatic disease may be associated with minimal elevations of human chorionic gonadotropin (hCG). Here we present an unusual case of a patient with PSTT and an isolated breast metastasis who was successfully treated with surgical resection and single-agent chemotherapy.
胎盘部位滋养细胞肿瘤（PSTT）是妊娠滋养细胞肿瘤（GTN）的一种罕见形式。它最常发生在分娩后，但也可能在任何类型的妊娠后出现。PSTT由中间型滋养细胞的肿瘤性转化引起。最常报告的症状是异常出血或闭经。由于这种疾病罕见，关于预后因素以及最佳治疗的证据有限。虽然早期疾病的治疗通常仅限于手术，但化疗和手术的多模式治疗对转移性疾病可能很重要。转移性疾病可能与人类绒毛膜促性腺激素（hCG）的轻微升高有关。在此，我们报告一例不寻常的PSTT患者，其发生孤立性乳腺转移，经手术切除和单药化疗成功治疗。
