KAT2介导的PLK4乙酰化通过维持中心体数量来促进基因组稳定性。
KAT2-mediated PLK4 acetylation contributes to genomic stability by preserving centrosome number.
作者信息
Fournier Marjorie, Tora László
机构信息
Sir William Dunn School of Pathology, University of Oxford , Oxford, UK.
Development and Stem Cell Department, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France; Centre National de la Recherche Scientifique, UMR7104, Illkirch, France; Institut National de la Santé et de la Recherche Médicale, U964, Illkirch, France; Université de Strasbourg, Illkirch, France.
出版信息
Mol Cell Oncol. 2016 Dec 16;4(2):e1270391. doi: 10.1080/23723556.2016.1270391. eCollection 2017.
We have recently identified the first human lysine (K) acetyltransferase 2A and 2B (called KAT2A/2B; known also as GCN5/PCAF, respectively)-dependent acetylome and revealed a mechanism by which KAT2A/2B-mediated acetylation of serine/threonine polo-like kinase 4 (PLK4) maintains correct centrosome number in human cells, therefore contributing to the maintenance of genome stability..
我们最近鉴定出了首个依赖人类赖氨酸（K）乙酰转移酶2A和2B（分别称为KAT2A/2B；也分别称为GCN5/PCAF）的乙酰化蛋白质组，并揭示了一种机制，通过该机制KAT2A/2B介导的丝氨酸/苏氨酸polo样激酶4（PLK4）的乙酰化作用维持人类细胞中正确的中心体数量，从而有助于维持基因组稳定性。
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