Zhang Xiaoyang, Wei Cheng, Liang Hao, Han Lei
Tianjin Neurological Institute, Key Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin Medical University General Hospital, Tianjin, China.
Front Oncol. 2021 Mar 12;11:587554. doi: 10.3389/fonc.2021.587554. eCollection 2021.
Polo-like kinases (Plks) are critical regulatory molecules during the cell cycle process. This family has five members: Plk1, 2, 3, 4, and 5. Plk4 has been identified as a master regulator of centriole replication, and its aberrant expression is closely associated with cancer development. In this review, we depict the DNA, mRNA, and protein structure of Plk4, and the regulation of Plk4 at a molecular level. Then we list the downstream targets of Plk4 and the hallmarks of cancer associated with these targets. The role of Plk4 in different cancers is also summarized. Finally, we review the inhibitors that target Plk4 in the hope of discovering effective anticancer drugs. From authors' perspective, Plk4 might represent a valuable tumor biomarker and critical target for cancer diagnosis and therapy.
Polo样激酶（Plks）是细胞周期进程中的关键调节分子。该家族有五个成员：Plk1、2、3、4和5。Plk4已被确定为中心粒复制的主要调节因子，其异常表达与癌症发展密切相关。在这篇综述中，我们描述了Plk4的DNA、mRNA和蛋白质结构，以及分子水平上对Plk4的调控。然后我们列出了Plk4的下游靶点以及与这些靶点相关的癌症特征。还总结了Plk4在不同癌症中的作用。最后，我们综述了靶向Plk4的抑制剂，以期发现有效的抗癌药物。从作者的角度来看，Plk4可能是一种有价值的肿瘤生物标志物，也是癌症诊断和治疗的关键靶点。
