一种使用两种新型铈基纳米复合亲和探针的组合策略，用于在质谱分析中选择性富集单磷酸肽和多磷酸肽。
A combination strategy using two novel cerium-based nanocomposite affinity probes for the selective enrichment of mono- and multi-phosphopeptides in mass spectrometric analysis.
作者信息
Long Xing-Yu, Zhang Zi-Jin, Li Jia-Yuan, Sheng Dong, Lian Hong-Zhen
机构信息
State Key Laboratory of Analytical Chemistry for Life Science, Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry & Chemical Engineering and Center of Materials Analysis, Nanjing University, 163 Xianlin Avenue, Nanjing 210023, P. R. China.
出版信息
Chem Commun (Camb). 2017 Apr 20;53(33):4620-4623. doi: 10.1039/c7cc00540g.
This work presents a sequential enrichment protocol, based on two self-designed cerium-based nanocomposite affinity probes, which not only can effectively separate phosphopeptides from non-phosphopeptides but can also selectively differentiate mono- and multi-phosphopeptides for direct matrix-assisted laser desorption/ionization time-of-flight mass spectrometric (MALDI-TOF MS) analysis.
这项工作提出了一种基于两种自行设计的铈基纳米复合亲和探针的顺序富集方案，该方案不仅可以有效地从非磷酸肽中分离磷酸肽，还可以选择性地区分单磷酸肽和多磷酸肽，用于直接基质辅助激光解吸/电离飞行时间质谱（MALDI-TOF MS）分析。
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