基于蛋白质诱导的G-四链体开关解折叠的抗体一步比色检测。
One-step colorimetric detection of an antibody based on protein-induced unfolding of a G-quadruplex switch.
作者信息
Hu Xiaolu, Li Chao, Feng Chang, Mao Xiaoxia, Xiang Yang, Li Genxi
机构信息
State Key Laboratory of Pharmaceutical Biotechnology and Collaborative Innovation Center of Chemistry for Life Sciences, Department of Biochemistry, Nanjing University, Nanjing 210093, P. R. China.
出版信息
Chem Commun (Camb). 2017 Apr 25;53(34):4692-4694. doi: 10.1039/c7cc00687j.
PMID:28401205
Abstract
A simple colorimetric assay is developed for the sensitive and selective detection of an antibody, which combines a protein binding-induced signaling approach with a novel DNAzyme-based conformational switching strategy.
摘要
开发了一种简单的比色测定法，用于灵敏且选择性地检测抗体，该方法将蛋白质结合诱导的信号传导方法与基于新型脱氧核酶的构象转换策略相结合。
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