NanoBioelectronics Laboratory, Department of Biotechnology, Delhi Technological University, Main Bawana Road, Delhi 110042, India.
Biomater Sci. 2017 May 2;5(5):901-952. doi: 10.1039/c7bm00008a.
One of the major challenges in our contemporary society is to facilitate healthy life for all human beings. In this context, cancer has become one of the most deadly diseases around the world, and despite many advances in theranostics techniques the treatment of cancer still remains an important problem. With recent advances made in the field of nano-biotechnology, carbon-based nanostructured materials have drawn special attention because of their unique physicochemical properties, giving rise to great potential for the diagnosis and therapy of cancer. This review deals with four different types of carbon allotrope including carbon nanotubes, graphene, fullerenes and nanodiamonds and summarizes the results of recent studies that are likely to have implications in cancer theranostics. We discuss the applications of these carbon allotropes for cancer imaging and drug delivery, hyperthermia, photodynamic therapy and acoustic wave assisted theranostics. We focus on the results of different studies conducted on functionalized/conjugated carbon nanotubes, graphene, fullerenes and nanodiamond based nanostructured materials reported in the literature in the current decade. The emphasis has been placed on the synthesis strategies, structural design, properties and possible mechanisms that are perhaps responsible for their improved theranostic characteristics. Finally, we discuss the critical issues that may accelerate the development of carbon-based nanostructured materials for application in cancer theranostics.
在当代社会，一个主要的挑战是促进全人类的健康生活。在这种情况下，癌症已成为全球最致命的疾病之一，尽管治疗癌症的治疗方法在治疗方法方面取得了许多进展，但治疗癌症仍然是一个重要的问题。随着纳米生物技术领域的最新进展，基于碳的纳米结构材料因其独特的物理化学性质而引起了特别关注，为癌症的诊断和治疗带来了巨大的潜力。这篇综述涉及包括碳纳米管、石墨烯、富勒烯和纳米金刚石在内的四种不同类型的碳同素异形体，并总结了最近可能对癌症治疗产生影响的研究结果。我们讨论了这些碳同素异形体在癌症成像和药物输送、热疗、光动力治疗和声波辅助治疗中的应用。我们专注于在当前十年文献中报道的功能化/共轭碳纳米管、石墨烯、富勒烯和纳米金刚石基纳米结构材料的不同研究结果。重点介绍了它们可能负责改善治疗特性的合成策略、结构设计、性质和可能的机制。最后，我们讨论了可能加速将基于碳的纳米结构材料应用于癌症治疗的关键问题。
