Mino N, Iio A, Hamamoto K
Department of Radiology, School of Medicine, Ehime University, Japan.
Cancer. 1988 Aug 15;62(4):730-4. doi: 10.1002/1097-0142(19880815)62:4<730::aid-cncr2820620415>3.0.co;2-w.
The serum level of tumor-antigen 4 (TA-4) was measured in 401 patients with squamous cell carcinoma (SCC) of various organs (76 lung, 82 esophagus, and 234 head and neck). The mean serum level of TA-4 in patients with lung SCC was 3.6 times higher than that in healthy controls and even higher in the advanced stages of disease (III, IV). In patients with benign diseases or other types of lung cancer, however, the TA-4 serum level was not different from the controls regardless of the clinical stage. During radiation therapy, the TA-4 levels in patients with lung SCC decreased with reduction in tumor size. It increased again markedly during recurrence. Similarly, patients with SCC of the esophagus and head and neck also showed elevated TA-4 levels but only at advanced stages and in recurrence. It was concluded that TA-4 is highly related to SCC not only of the uterine cervix but also of other organs and that serum level determinations are useful for monitoring therapeutic effects and recurrence of these diseases, despite some limitations.
对401例各器官鳞状细胞癌（SCC）患者（76例肺癌、82例食管癌和234例头颈癌）检测了肿瘤抗原4（TA-4）的血清水平。肺癌SCC患者的TA-4平均血清水平比健康对照者高3.6倍，在疾病晚期（III、IV期）甚至更高。然而，患有良性疾病或其他类型肺癌的患者，无论临床分期如何，TA-4血清水平与对照者无差异。在放射治疗期间，肺癌SCC患者的TA-4水平随肿瘤大小的减小而降低。复发期间它又明显升高。同样，食管癌和头颈癌SCC患者也显示TA-4水平升高，但仅在晚期和复发时。得出的结论是，TA-4不仅与子宫颈SCC高度相关，而且与其他器官的SCC也高度相关，尽管有一些局限性，但血清水平测定对于监测这些疾病的治疗效果和复发是有用的。
