Molina R, Filella X, Torres M D, Ballesta A M, Mengual P, Cases A, Balaque A
Laboratory of Clinical Biochemistry (Unit for Cancer Research), Hospital Clinico y Provincial, Medical School, Barcelona, Spain.
Clin Chem. 1990 Feb;36(2):251-4.
SCC antigen was measured in the serum of 214 patients with benign diseases and in 251 patients with various cancers. With 2.5 micrograms/L as the upper normal limit for serum, values were positive in 2.9% of 69 healthy subjects (I), 29.0% of 214 patients with benign pathologies (II), and 41% of 217 patients with active cancer (III). The highest values in group II were for patients in renal failure (64%) or with lung diseases (40%) or head-and-neck diseases (21.2%). Specificity of SCC increased (91.1%) when we excluded patients in renal failure or with creatinine values greater than 133 mumol/L. In group III, SCC values were abnormal in 57.7% of patients with squamous cell carcinoma, but in only 9.3% of those with other histological types (P less than 0.001). In squamous cell carcinoma of the lung, cervix, or head and neck, SCC values were related to tumor stage, values being highest in patients with metastases.
在214例良性疾病患者和251例各类癌症患者的血清中检测了鳞状细胞癌抗原。以血清2.5微克/升作为正常上限，69名健康受试者（I组）中有2.9%的人检测值呈阳性，214例良性病变患者（II组）中有29.0%呈阳性，217例活动性癌症患者（III组）中有41%呈阳性。II组中检测值最高的是肾衰竭患者（64%）、肺部疾病患者（40%）或头颈疾病患者（21.2%）。当我们排除肾衰竭患者或肌酐值大于133微摩尔/升的患者时，鳞状细胞癌抗原的特异性提高（91.1%）。在III组中，鳞状细胞癌患者中有57.7%的人鳞状细胞癌抗原检测值异常，而其他组织学类型的患者中只有9.3%异常（P<0.001）。在肺、宫颈或头颈鳞状细胞癌中，鳞状细胞癌抗原检测值与肿瘤分期有关，转移患者的值最高。
