Słomian Grzegorz, Świętochowska Elżbieta, Nowak Grzegorz, Pawlas Krystyna, Żelazko Aleksandra, Nowak Przemysław
Oncological Ward, Independent Public Health Care Unit, Voivodeship Specialized Hospital No. 3, Rybnik, Poland.
Department of Clinical Biochemistry, Medical University of Silesia, Poland.
Postepy Hig Med Dosw (Online). 2017 Apr 12;71(0):281-290. doi: 10.5604/01.3001.0010.3813.
Adipokines are molecules produced and secreted by adipose tissue and are linked to multiple malignancies. Adipokines can suppress or promote particular cell behaviors in different types of cancer. The aim of this study was to investigate the impact of chemotherapy on select adipokines in patients with colorectal cancer (CRC). Blood samples were collected from 42 patients with pathologically documented advanced CRC, who required palliative chemotherapy. Leptin, adiponectin, resistin and visfatin levels were measured by ELISA before and 3 months after the administration of chemotherapy. Among the 42 patients evaluated, 18 achieved a partial response (PR), 16 achieved stable disease (SD) and 8 patients experienced disease progression (PD). We found that 5-fluorouracil-based chemotherapy regimens significantly increased plasma levels of leptin and adiponectin and decreased plasma levels of resistin and visfatin in PR and SD patients, whereas the plasma levels of these molecules were not affected in PD patients. Furthermore, the mean plasma levels of leptin were significantly lower, and the mean plasma levels of resistin and visfatin were significantly greater in patients with PD compared with PR and SD both before and after chemotherapy treatment. We conclude that palliative chemotherapy in CRC patients, in addition to providing clinical benefits, positively affects cytokine production and secretion in PR and SD patients. Specifically, we found that palliative chemotherapy increased plasma levels of the anti-inflammatory adipokine adiponectin and decreased the plasma levels of visfatin and resistin, molecules known to promote angiogenesis and cancer cell proliferation in PR and SD patients. Moreover, the baseline values of leptin, visfatin and resistin might serve as prognostic indicators of a poor response to chemotherapy.
脂肪因子是由脂肪组织产生和分泌的分子，与多种恶性肿瘤相关。脂肪因子可抑制或促进不同类型癌症中的特定细胞行为。本研究的目的是调查化疗对结直肠癌（CRC）患者特定脂肪因子的影响。收集了42例经病理证实为晚期CRC且需要姑息化疗的患者的血样。在化疗给药前和给药3个月后，通过酶联免疫吸附测定法（ELISA）测量瘦素、脂联素、抵抗素和内脂素水平。在评估的42例患者中，18例达到部分缓解（PR），16例疾病稳定（SD），8例疾病进展（PD）。我们发现，基于5-氟尿嘧啶的化疗方案显著提高了PR和SD患者血浆中瘦素和脂联素的水平，降低了抵抗素和内脂素的血浆水平，而这些分子的血浆水平在PD患者中未受影响。此外，与PR和SD患者相比，PD患者化疗前后血浆瘦素的平均水平显著较低，而抵抗素和内脂素的平均水平显著较高。我们得出结论，CRC患者的姑息化疗除了提供临床益处外，还对PR和SD患者的细胞因子产生和分泌有积极影响。具体而言，我们发现姑息化疗提高了抗炎脂肪因子脂联素的血浆水平，并降低了内脂素和抵抗素的血浆水平，已知这些分子在PR和SD患者中促进血管生成和癌细胞增殖。此外，瘦素、内脂素和抵抗素的基线值可能作为化疗反应不佳的预后指标。
