Department of Chemical Engineering, Feng Chia University, 100, Wenhwa Road, Seatwen, Taichung 40724, Taiwan, ROC.
Department of Surgery, Taichung Veterans General Hospital, 1650 Taiwan Boulevard Section 4, Taichung 40705, Taiwan, ROC.
J Hazard Mater. 2017 Jul 15;334:93-103. doi: 10.1016/j.jhazmat.2017.04.001. Epub 2017 Apr 3.
Cyanide (CN̄) is one of the most toxic material to the human and environment. It is very important to develop the diagnostic tools for the detection of CN̄ ions. Moreover, detection of the ions in an aqueous medium is a challenging task as water molecules interfere with the sensing mechanism. In this context, we prepared chemical sensor, S1, having anthraquinone as a signaling unit and thiourea as a binding site. This sensor exhibited distinct visual color and spectral changes in response to CN̄ ion over other testing anions in 50% aq. DMSO solution. However, in 20% aq. DMSO solution, S1 exhibited obvious spectral and color changes in response to CN̄, fluoride (F̄), acetate (Ac̄) and benzoate (Bz̄). Another sensor, S2, having a same signaling unit with that of S1, but a different binding site of urea group. In contrast to S1, S2 exhibited obvious spectral and color changes to F̄ in 2.5% aq. DMSO solution. NMR titration results suggested that the spectral and colorimetric responses were due to the formation of host-guest complex and deprotonation events. Finally, economically viable paper-based colorimetric "test stripes" of S1 were fabricated to detect the CN̄ ions in 100% aqueous solution.
氰化物 (CN̄) 对人类和环境是最具毒性的物质之一。开发用于检测 CN̄离子的诊断工具非常重要。此外，由于水分子会干扰感测机制，因此在水溶液中检测离子是一项具有挑战性的任务。在这种情况下，我们制备了具有蒽醌作为信号单元和硫脲作为结合位点的化学传感器 S1。该传感器在 50% aq.DMSO 溶液中对 CN̄离子表现出明显的视觉颜色和光谱变化，而对其他测试阴离子则没有。然而，在 20% aq.DMSO 溶液中，S1 对 CN̄、氟化物 (F̄)、乙酸盐 (Ac̄) 和苯甲酸盐 (Bz̄) 表现出明显的光谱和颜色变化。另一个传感器 S2 具有与 S1 相同的信号单元，但结合位点为脲基团。与 S1 相反，S2 在 2.5% aq.DMSO 溶液中对 F̄表现出明显的光谱和颜色变化。NMR 滴定结果表明，光谱和比色响应是由于形成主体-客体配合物和去质子化事件。最后，制备了经济可行的基于纸张的 S1 比色“测试条”，以检测 100%水溶液中的 CN̄离子。
