Kofman O, Levin U
Department of Behavioural Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.
Psychopharmacology (Berl). 1995 Mar;118(2):213-8. doi: 10.1007/BF02245842.
Lithium elicits opposite effects on two behavioural syndromes in rats: enhancement of the 5-HT1A-linked serotonin syndrome and attenuation of the 5-HT2-linked wet dog shakes. The ability of intracerebroventricular (ICV) myo-inositol or forskolin to reverse the enhancement of the serotonin syndrome by lithium was tested in rats that were fed chronic dietary lithium or control diet and injected with the serotonin agonist 5-MeODMT (5-methoxy-N, N-dimethyltryptamine). Lithium enhanced the total serotonin syndrome score and particularly flat posture and tremor. Inositol, but not forskolin, mitigated the effects of lithium. Inositol was also injected in the lateral ventricle of rats pretreated with chronic dietary lithium or regular rat chow for 3 weeks and injected with carbidopa and L-5-hydroxytryptophan (5-HTP). Lithium attenuated wet dog shakes, but inositol had no significant effect on lithium-treated or control rats. These findings suggest that the enhancement of the serotonin syndrome by lithium may be related to lithium-induced inositol depletion.
增强与5-HT1A相关的血清素综合征，减弱与5-HT2相关的湿狗样抖动。在喂食慢性膳食锂或对照饮食并注射血清素激动剂5-甲氧基-N，N-二甲基色胺（5-MeODMT）的大鼠中，测试了脑室内（ICV）注射肌醇或福司可林逆转锂对血清素综合征增强作用的能力。锂提高了血清素综合征的总分，特别是平卧位姿势和震颤。肌醇而非福司可林减轻了锂的作用。对用慢性膳食锂或常规大鼠饲料预处理3周并注射卡比多巴和L-5-羟色氨酸（5-HTP）的大鼠侧脑室注射肌醇。锂减弱了湿狗样抖动，但肌醇对锂处理的大鼠或对照大鼠没有显著影响。这些发现表明，锂对血清素综合征的增强作用可能与锂诱导的肌醇耗竭有关。
