Joas Erik, Guo Xinxin, Kern Silke, Östling Svante, Skoog Ingmar
Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
J Hypertens. 2017 Jul;35(7):1424-1431. doi: 10.1097/HJH.0000000000001348.
The aim of this study was to analyze the influence of birth cohort, sex and age on the trajectories of SBP and DBP in two birth cohorts of 70-year-olds, examined 3 decades apart and followed up at ages 75 and 79-80 years.
Two population samples of 70-year-olds from Gothenburg, Sweden, were examined. The first, born in 1901-1902, was examined in 1971-1972 (n = 973). The second, born in 1930, was examined in 2000 (n = 509). Both samples were re-examined at ages 75 and 79-80 years.
We found that SBP and DBP were considerably lower in septuagenarian men and women born 1930 compared with those born 1901-1902, also when adjusting for antihypertensive treatment in different ways. The decline was especially pronounced in women. Blood pressure was higher in women than in men in the 1970s, whereas there were no sex differences in the 2000s. The age-related decline in SBP started earlier and was more accentuated in those born in 1930 than in those born in 1901-1902.
Blood pressure decreased, and the age-related decline in SBP started earlier in septuagenarians examined in the 2000s compared with those examined in the 1970s. The decrease was especially pronounced in women and diminished the sex differences. Antihypertensive treatment only partly explained our findings, suggesting that other mostly unknown factors played an important role.
本研究旨在分析出生队列、性别和年龄对两组70岁出生队列收缩压（SBP）和舒张压（DBP）轨迹的影响，这两组队列相隔30年进行检查，并在75岁以及79 - 80岁时进行随访。
对来自瑞典哥德堡的两组70岁人群样本进行检查。第一组出生于1901 - 1902年，于1971 - 1972年接受检查（n = 973）。第二组出生于1930年，于2000年接受检查（n = 509）。两组样本均在75岁以及79 - 80岁时再次接受检查。
我们发现，与出生于1901 - 1902年的70岁男性和女性相比，出生于1930年的70岁男性和女性的收缩压和舒张压显著更低，即使以不同方式调整抗高血压治疗后也是如此。这种下降在女性中尤为明显。20世纪70年代女性血压高于男性，而在21世纪则没有性别差异。与出生于1901 - 1902年的人相比，出生于1930年的人收缩压与年龄相关的下降开始得更早且更为明显。
与20世纪70年代接受检查的70岁人群相比，21世纪接受检查的70岁人群血压下降，且收缩压与年龄相关的下降开始得更早。这种下降在女性中尤为明显，并缩小了性别差异。抗高血压治疗仅部分解释了我们的研究结果，表明其他大多未知的因素起到了重要作用。
