Su Zhongqian, Chen Zhibo, Xiang Yian, Wang Bingjie, Huang Yuanyuan, Yang Dehao, Li Xiang, Weng Yiyun, Lin XianFeng, Chen Guoqian, Liu Wenyue, Zhao Chenchen, Wang Qingqing, Li Shanshan, Chen Ying, Chen Ying, Quan Weiwei, Tong Qiuling, Wu Shengjie, Huang Shihao, Mei Peina, Li Zhengzheng, Li Jia, Hou Shengtao, Zhang Xu
Department of Neurology, Wenzhou Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai Department of Orthopedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou Department of Endocrinology, Wenzhou Department of Orthopedic Surgery, The Second Affiliated Hospital, Medical College of Zhejiang University, Hangzhou Department of Orthopedic Surgery, The Second Affiliated Hospital of Wenzhou Medical University Department of Infection and Liver Diseases, Liver Research Center Department of Cardiovascular Medicine, The Heart Center Department of Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou Brain Research Centre and Department of Biology, Southern University of Science and Technology, Shenzhen, China.
Medicine (Baltimore). 2017 Apr;96(15):e6618. doi: 10.1097/MD.0000000000006618.
Free radical toxicity due to poorly maintained cellular redox levels is crucial events that have been associated with the pathogenesis of Guillain-Barre syndrome (GBS) patients. Uric acid (UA) and albumin correlate with oxidative stress in some degree. We aimed to evaluate the relationship between GBS and serum levels of UA and albumin in the present study.The serum levels of UA and albumin were determined in 203 individuals including 88 patients with GBS and 153 healthy controls (HC).We found that serum levels of UA and albumin in patients with GBS were significantly lower than those in HC group. Besides, similar phenomenon was observed when the male and female subgroups were estimated, respectively. Additionally, we found that there is no statistic difference among subgroups of GBS regarding UA and albumin. The univariate analysis revealed that both the high UA and high albumin were protective factors for patients with GBS (odds ratio [OR] 0.140; 95% confidence interval [CI]: 0.074-0.264; P < .001 and OR 0.016; 95% CI: 0.006-0.038; P < .001, respectively). It was further confirmed by the multivariable logistic regression analysis after adjusting for other potential confounding factors (OR 0.168; 95% CI: 0.055-0.514; P = .002 and OR 0.027; 95% CI: 0.011-0.071; P < .001, respectively).In conclusion, we found that patients with GBS had significantly low serum UA and albumin levels. Moreover, we demonstrated that both the high UA and high albumin were protective factors for patients with GBS.
细胞氧化还原水平维持不佳导致的自由基毒性是与吉兰 - 巴雷综合征（GBS）患者发病机制相关的关键事件。尿酸（UA）和白蛋白在一定程度上与氧化应激相关。在本研究中，我们旨在评估GBS与血清UA和白蛋白水平之间的关系。我们测定了203名个体的血清UA和白蛋白水平，其中包括88例GBS患者和153名健康对照（HC）。我们发现GBS患者的血清UA和白蛋白水平显著低于HC组。此外，在分别评估男性和女性亚组时也观察到了类似现象。此外，我们发现GBS各亚组之间在UA和白蛋白方面没有统计学差异。单因素分析显示，高UA和高白蛋白都是GBS患者的保护因素（优势比[OR] 0.140；95%置信区间[CI]：0.074 - 0.264；P＜0.001和OR 0.016；95% CI：0.006 - 0.038；P＜0.001）。在调整其他潜在混杂因素后，多变量逻辑回归分析进一步证实了这一点（OR 0.168；95% CI：0.055 - 0.514；P = 0.002和OR 0.027；95% CI：0.011 - 0.071；P＜0.001）。总之，我们发现GBS患者的血清UA和白蛋白水平显著降低。此外，我们证明高UA和高白蛋白都是GBS患者的保护因素。
