Low Jenny G H, Ooi Eng Eong, Vasudevan Subhash G
Department of Infectious Diseases, Singapore General Hospital.
Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School.
J Infect Dis. 2017 Mar 1;215(suppl_2):S96-S102. doi: 10.1093/infdis/jiw423.
Dengue is a significant global health problem. Even though a vaccine against dengue is now available, which is a notable achievement, its long-term protective efficacy against each of the 4 dengue virus serotypes remains to be definitively determined. Consequently, drugs directed at the viral targets or critical host mechanisms that can be used safely as prophylaxis or treatment to effectively ameliorate disease or reduce disease severity and fatalities are still needed to reduce the burden of dengue. This review will provide a brief account of the status of therapeutics research and development for dengue.
登革热是一个重大的全球健康问题。尽管现在有一种针对登革热的疫苗，这是一项显著成就，但其针对4种登革热病毒血清型中每一种的长期保护效力仍有待明确确定。因此，仍需要针对病毒靶点或关键宿主机制的药物，这些药物可安全地用作预防或治疗药物，以有效改善疾病或降低疾病严重程度和死亡率，从而减轻登革热的负担。本综述将简要介绍登革热治疗研究与开发的现状。
