Belda Raquel, García-España Enrique, Morris Gareth A, Steed Jonathan W, Aguilar Juan A
Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK.
Instituto de Ciencia Molecular, Universidad de Valencia, C/ Catedrático José Beltrán n°. 2, 46980, Paterna, Spain.
Chemistry. 2017 Jun 7;23(32):7755-7760. doi: 10.1002/chem.201700642. Epub 2017 May 22.
The self-assembling tendencies of guanosine-5'-monophosphate (GMP) can be drastically increased using polyamines, with potential applications in the production of biocompatible smart materials, as well as for the design of antitumor drugs based on G-quadruplex stabilization. Results from scanning electron microscopy (SEM), wide angle X-ray scattering (WAXS), rheology, and nuclear magnetic resonance (NMR) z-spectroscopy studies are presented.
使用多胺可大幅增强5'-鸟苷单磷酸（GMP）的自组装倾向，这在生物相容性智能材料的生产以及基于G-四链体稳定化的抗肿瘤药物设计方面具有潜在应用。本文展示了扫描电子显微镜（SEM）、广角X射线散射（WAXS）、流变学和核磁共振（NMR）z光谱研究的结果。
