Kou Xianjuan, Fan Jingjing, Chen Ning
Tianjiu Research and Development Center for Exercise Nutrition and Foods, Hubei Key Laboratory of Sport Training and Monitoring, College of Health Science, Wuhan Sports University, Wuhan 430079. China.
Anticancer Agents Med Chem. 2017;17(12):1610-1616. doi: 10.2174/1871521409666170412130529.
Cancers have increased threat to human health due to the limited treatment efficacy of chemotherapy and radiotherapy with a series of toxicity and side effects; therefore, the development and utilization of natural products with potential preventive and therapeutic efficacy, and less toxicity and side effects will be beneficial to promote the health of cancer patients. In this article, the activity of ampelopsin as a natural flavonoid and its underlying molecular mechanisms for the prevention and treatments of hepatic carcinoma, breast cancer, prostate cancer and melanoma through inhibiting cell proliferation, accelerating apoptosis, inducing reactive oxygen species (ROS) generation and endoplasmic reticulum (ER) stress, suppressing angiogenesis, invasion and metastasis, and synergizing the efficacy of other anti-cancer drugs have been summarized. This study will provide a reference for the development and utilization of other natural products.
由于化疗和放疗的治疗效果有限且伴有一系列毒性和副作用，癌症对人类健康的威胁日益增加；因此，开发和利用具有潜在预防和治疗功效、毒性和副作用较小的天然产物将有助于促进癌症患者的健康。本文综述了天然黄酮类化合物白藜芦醇的活性及其通过抑制细胞增殖、加速细胞凋亡、诱导活性氧（ROS）生成和内质网（ER）应激、抑制血管生成、侵袭和转移以及协同其他抗癌药物的疗效来预防和治疗肝癌、乳腺癌、前列腺癌和黑色素瘤的潜在分子机制。本研究将为其他天然产物的开发和利用提供参考。
