超声辅助在 SnCl2·2H2O 作为前催化剂存在的条件下合成喹啉衍生物：评估其抗菌活性。
Ultrasound Assisted Synthesis of Quinoline Derivatives in the Presence of SnCl2·2H2O as a Precatalyst in Water: Evaluation of their Antibacterial Activities.
机构信息
Department of Chemistry, K.L. University, Vaddeswaram Guntur-522502, Andhra Pradesh, India.
Department of Chemistry and The National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Be'er-Sheva 84105, Israel.
出版信息
Mini Rev Med Chem. 2018;18(10):895-903. doi: 10.2174/1389557517666170412112619.
BACKGROUND
SnCl2·2H2O has been used as a convenient precatalyst for the one-pot and rapid synthesis of 2-substituted quinolines under ultrasound irradiation in water. The reaction involved a 3-component reaction of aniline, aldehydes, and ethyl 3,3-diethoxypropionate in the presence of aerial oxygen to give the desired products in good yields.
CONCLUSION
Several of these compounds showed antibacterial activities when tested against gram-positive and gram-negative species. One compound i.e. 4b showed promising activities across both the species.
背景
SnCl2·2H2O 已被用作超声辐射下水相中一锅法快速合成 2-取代喹啉的方便前体。该反应涉及苯胺、醛和乙基 3,3-二乙氧基丙酸酯的 3 组分反应，在有氧存在下得到所需产物，产率良好。
结论
当测试对革兰氏阳性和革兰氏阴性物种的抗菌活性时，这些化合物中的几种显示出抗菌活性。一种化合物即 4b 在两种物种中都表现出有希望的活性。
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