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7-羟基-4-苯基-1,2-二氢喹啉衍生物:通过一锅三组分反应合成及结构解析

7-Hydroxy-4-phenyl-1, 2-dihydroquinoline derivatives: synthesis via one-pot, three-component reaction and structure elucidation.

作者信息

Tabassum Rukhsana, Ashfaq Muhammad, Oku Hiroyuki

机构信息

Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, 36100, Pakistan.

Division of Molecular Science, Graduate School of Science &Engineering Gunma University, Gunma, 376-8515, Japan.

出版信息

Heliyon. 2020 Sep;6(9):e05035. doi: 10.1016/j.heliyon.2020.e05035. Epub 2020 Oct 1.

Abstract

We have developed a new and facile one pot three component protocol catalyzed by ammonium acetate for construction of new functionalized 7-hydroxy-4-phenyl-1,2-dihydroquinoline derivatives. A variety of quinoline derivatives were obtained in good to excellent yield from inexpensive reagents and catalyst in mild reaction conditions that provide atom economy and cost efficacy. Various spectroscopic techniques like FTIR, HNMR and CNMR were employed to study their structure while mass of the synthesized compounds were confirmed through MALDI-TOF-MS and EI mass spectrometry.

摘要

我们开发了一种由醋酸铵催化的新型简便一锅三组分反应体系,用于构建新型官能化的7-羟基-4-苯基-1,2-二氢喹啉衍生物。在温和的反应条件下,以廉价的试剂和催化剂,高收率地获得了多种喹啉衍生物,该反应具有原子经济性和成本效益。采用傅里叶变换红外光谱(FTIR)、核磁共振氢谱(HNMR)和核磁共振碳谱(CNMR)等多种光谱技术研究其结构,同时通过基质辅助激光解吸电离飞行时间质谱(MALDI-TOF-MS)和电子轰击质谱(EI质谱)确认合成化合物的分子量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e246/7534183/a593cf72cca7/gr1.jpg

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