Owusu-Edusei K, Cramer R, Chesson H W, Gift T L, Leichliter J S
Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
Public Health. 2017 Jun;147:101-108. doi: 10.1016/j.puhe.2017.02.012. Epub 2017 Mar 24.
In this study, we examined state-level monthly gonorrhea morbidity and assessed the potential impact of existing expedited partner therapy (EPT) laws in relation to the time that the laws were enacted.
Longitudinal study.
We obtained state-level monthly gonorrhea morbidity (number of cases/100,000 for males, females and total) from the national surveillance data. We used visual examination (of morbidity trends) and an autoregressive time series model in a panel format with intervention (interrupted time series) analysis to assess the impact of state EPT laws based on the months in which the laws were enacted.
For over 84% of the states with EPT laws, the monthly morbidity trends did not show any noticeable decreases on or after the laws were enacted. Although we found statistically significant decreases in gonorrhea morbidity within four of the states with EPT laws (Alaska, Illinois, Minnesota, and Vermont), there were no significant decreases when the decreases in the four states were compared contemporaneously with the decreases in states that do not have the laws.
We found no impact (decrease in gonorrhea morbidity) attributable exclusively to the EPT law(s). However, these results do not imply that the EPT laws themselves were not effective (or failed to reduce gonorrhea morbidity), because the effectiveness of the EPT law is dependent on necessary intermediate events/outcomes, including sexually transmitted infection service providers' awareness and practice, as well as acceptance by patients and their partners.
在本研究中,我们调查了州级每月淋病发病率,并评估了现有加速性伴侣治疗(EPT)法律在颁布时间方面的潜在影响。
纵向研究。
我们从国家监测数据中获取了州级每月淋病发病率(男性、女性及总计的病例数/10万)。我们使用(发病率趋势的)视觉检查以及带有干预(中断时间序列)分析的面板形式自回归时间序列模型,根据法律颁布的月份来评估州EPT法律的影响。
在拥有EPT法律的州中,超过84%的州在法律颁布时及之后每月发病率趋势未显示出任何明显下降。尽管我们发现有EPT法律的四个州(阿拉斯加、伊利诺伊、明尼苏达和佛蒙特)内淋病发病率有统计学上的显著下降,但将这四个州的下降情况与没有该法律的州同期下降情况相比较时,并无显著下降。
我们未发现仅归因于EPT法律的影响(淋病发病率下降)。然而,这些结果并不意味着EPT法律本身无效(或未能降低淋病发病率),因为EPT法律的有效性取决于必要的中间事件/结果,包括性传播感染服务提供者的意识和实践,以及患者及其伴侣的接受程度。