Chen Pengxiang, Han Lihui, Wang Cong, Jia Yibin, Song Qingxu, Wang Jianbo, Guan Shanghui, Tan Bingxu, Liu Bowen, Jia Wenqiao, Cui Jianfeng, Zhou Wei, Cheng Yufeng
Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, People's Republic of China.
Department of Urology, Qilu Hospital of Shandong University, Jinan, People's Republic of China.
Oncotarget. 2017 Jun 20;8(25):41605-41619. doi: 10.18632/oncotarget.15651.
This study was to evaluate the prognostic significance of serum lipids in esophageal squamous cell carcinoma patients who underwent esophagectomy. Preoperative serum lipids were collected from 214 patients who were diagnosed with esophageal squamous cell carcinoma. All of the patients received esophagectomy in Qilu Hospital of Shandong University from January 2007 to December 2008. The records and data were analyzed retrospectively. We found that low total cholesterol (for T stage, p = 0.006; for TNM stage, p = 0.039) and low-density lipoprotein cholesterol (for T stage, p = 0.031; for TNM stage, p = 0.035) were associated with advanced T stage and TNM stage. Kaplan-Meier survival analysis indicated that low total cholesterol and low-density lipoprotein cholesterol were associated with shorter disease-free survival(for total cholesterol, p = 0.045; for low-density lipoprotein cholesterol, p < 0.001) and overall survival (for total cholesterol, p = 0.043; for low-density lipoprotein cholesterol, p < 0.001). Lower low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio (LHR) indicated poorer disease-free survival and overall survival (both p < 0.001). In the multivariate analysis, low-density lipoprotein cholesterol and LHR were independent prognostic factors for disease-free survival and overall survival. In conclusion, our study indicated that preoperative serum total cholesterol and low-density lipoprotein cholesterol are prognostic factors for esophageal squamous cell carcinoma patients who underwent esophagectomy. LHR can serve as a promising serum lipids-based prognostic indicator.
本研究旨在评估接受食管切除术的食管鳞状细胞癌患者血清脂质的预后意义。收集了214例被诊断为食管鳞状细胞癌患者的术前血清脂质。所有患者于2007年1月至2008年12月在山东大学齐鲁医院接受了食管切除术。对记录和数据进行回顾性分析。我们发现，低总胆固醇（对于T分期，p = 0.006；对于TNM分期，p = 0.039）和低密度脂蛋白胆固醇（对于T分期，p = 0.031；对于TNM分期，p = 0.035）与晚期T分期和TNM分期相关。Kaplan-Meier生存分析表明，低总胆固醇和低密度脂蛋白胆固醇与无病生存期缩短（对于总胆固醇，p = 0.045；对于低密度脂蛋白胆固醇，p < 0.001）和总生存期缩短（对于总胆固醇，p = 0.043；对于低密度脂蛋白胆固醇，p < 0.001）相关。较低的低密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值（LHR）表明无病生存期和总生存期较差（两者p < 0.001）。在多变量分析中，低密度脂蛋白胆固醇和LHR是无病生存期和总生存期的独立预后因素。总之，我们的研究表明，术前血清总胆固醇和低密度脂蛋白胆固醇是接受食管切除术的食管鳞状细胞癌患者的预后因素。LHR可作为一种有前景的基于血清脂质的预后指标。
