Han Lihui, Song Qingxu, Jia Yibin, Chen Xuan, Wang Cong, Chen Pengxiang, Min Rui, Cheng Yufeng
Department of Radiation Oncology, Qilu Hospital of Shandong University, 107 West Wenhua Road, Jinan, 250012, People's Republic of China.
Tumour Biol. 2016 Mar;37(3):3081-90. doi: 10.1007/s13277-015-4152-1. Epub 2015 Sep 30.
The objective of this study was to investigate the clinical significance of systemic inflammation score (SIS) and prognostic nutritional index (PNI) in esophageal squamous cell carcinoma (ESCC) patients who underwent esophagectomy. Records from 206 patients with histologically diagnosed ESCC who underwent esophagectomy at Qilu Hospital of Shandong University from January 2007 to December 2008 were retrospectively reviewed. The median disease-free survival (DFS) of this cohort was 32.3 months and 5-year DFS was 34.5 %. The median overall survival (OS) was 39.5 months and 5-year OS was 40.8 %. We found that high SIS was significantly associated with increased tumor length (p = 0.021), increased depth of invasion (p = 0.001), lymph node metastasis (p = 0.038), and advanced pathological stage (p = 0.004). Kaplan-Meier survival analysis revealed that both high SIS and low PNI were significantly associated with inferior DFS (for the SIS, p = 0.005; for the PNI, p = 0.003) and OS (for the SIS, p = 0.007; for the PNI, p = 0.002). In multivariate analysis, SIS was an independent prognostic indicator for both DFS and OS. However, PNI was not an independent prognosticator in multivariate analysis. SIS was a novel and promising inflammation-based prognostic score than PNI in ESCC patients who underwent esophagectomy.
本研究的目的是探讨全身炎症评分（SIS）和预后营养指数（PNI）在接受食管切除术的食管鳞状细胞癌（ESCC）患者中的临床意义。回顾性分析了2007年1月至2008年12月在山东大学齐鲁医院接受食管切除术且经组织学确诊为ESCC的206例患者的记录。该队列的无病生存期（DFS）中位数为32.3个月，5年DFS率为34.5%。总生存期（OS）中位数为39.5个月，5年OS率为40.8%。我们发现高SIS与肿瘤长度增加（p = 0.021）、浸润深度增加（p = 0.001）、淋巴结转移（p = 0.038）及病理分期较晚（p = 0.004）显著相关。Kaplan-Meier生存分析显示，高SIS和低PNI均与较差的DFS（SIS，p = 0.005；PNI，p = 0.003）和OS（SIS，p = 0.007；PNI，p = 0.002）显著相关。多因素分析中，SIS是DFS和OS的独立预后指标。然而，PNI在多因素分析中不是独立的预后因素。在接受食管切除术的ESCC患者中，SIS是一种比PNI更新颖且有前景的基于炎症的预后评分。
