白细胞破碎性血管炎：对聚乙二醇化赛妥珠单抗的药物反应
Leukocytoclastic vasculitis drug reaction to certolizumab pegol.
作者信息
Woody Meghan, Warren Donald, Speck Laura, Jackson Julie
机构信息
University of Texas Dell Medical School, Austin, Texas (Woody); Baylor Scott & White, Marble Falls, Texas (Warren); and Westlake Dermatology, Austin, Texas (Speck, Jackson).
出版信息
Proc (Bayl Univ Med Cent). 2017 Apr;30(2):213-214. doi: 10.1080/08998280.2017.11929591.
Tumor necrosis factor (TNF)-alpha antagonists are a common treatment modality for autoimmune disorders, but their use can be associated with many side effects, including various dermatologic conditions. Certolizumab pegol, a newer TNF antagonist that lacks the Fc portion of the IgG antibody, has recently been approved to treat psoriatic arthritis, rheumatoid arthritis, and Crohn's disease. Though other TNF antagonists have been associated with leukocytoclastic vasculitis, this finding has not yet been reported with certolizumab pegol. We present a case report of leukocytoclastic vasculitis caused by certolizumab pegol.
肿瘤坏死因子（TNF）-α拮抗剂是治疗自身免疫性疾病的常用方法，但其使用可能会带来许多副作用，包括各种皮肤病。赛妥珠单抗聚乙二醇，一种新型的缺乏IgG抗体Fc部分的TNF拮抗剂，最近已被批准用于治疗银屑病关节炎、类风湿性关节炎和克罗恩病。尽管其他TNF拮抗剂与白细胞破碎性血管炎有关，但赛妥珠单抗聚乙二醇尚未有此相关报道。我们报告一例由赛妥珠单抗聚乙二醇引起的白细胞破碎性血管炎病例。
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