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纳米点光激发发光剂量计对治疗性电子束的响应。

Response of Nanodot Optically Stimulated Luminescence Dosimeters to Therapeutic Electron Beams.

作者信息

Ponmalar Y Retna, Manickam Ravikumar, Sathiyan S, Ganesh K M, Arun R, Godson Henry Finlay

机构信息

Department of Radiation Physics, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India; Department of Radiotherapy, Christian Medical College, Vellore, Tamil Nadu, India.

Department of Radiation Physics, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India.

出版信息

J Med Phys. 2017 Jan-Mar;42(1):42-47. doi: 10.4103/0971-6203.202424.

Abstract

Response of AlO:C-based nanoDot optically stimulated luminescence (OSL) dosimeter was studied for the dosimetry of 6, 9, 12, 16, and 20 MeV therapeutic electron beams. With reference to ionization chamber, no change in the response was observed with the change in the energy of electron beams for the field size from 6 cm × 6 cm to 25 cm × 25 cm, dose rates from 100 MU/min to 600 MU/min, and the linearity in the response up to 300 cGy. The fading of the transient signal was higher for 20 MeV electron beam than that of 6 MeV electron beam by about 5% as compared to value at 20 min after irradiation. The depletion of OSL signal per readout in 200 successive readouts was also found to change with dose and energy of electron beam from 6 MeV (9% and 12% per readout at 2 and 10 Gy, respectively) to 20 MeV (9% and 16% at 2 and 10 Gy, respectively). The OSL sensitivity changed in the range from 2% to 6% with accumulated doses from 2 to 8 Gy and with electron energy from 6 to 20 MeV, but the sensitivity could be reset using an optical annealing treatment. Although negligible fading for postirradiation storage from 20 min to several months, acceptable precision and linearity in the desired range, and high reproducibility makes nanoDot dosimeters very attractive for the dosimetry of therapeutic electron beams, a note should be made for changes in sensitivity at doses beyond 2 Gy and electron beams energy dependence in reuse, short-term fading, and signal depletion on repeated readout.

摘要

研究了基于AlO:C的纳米点光激发发光(OSL)剂量计对6、9、12、16和20 MeV治疗性电子束的剂量测定响应。参照电离室,对于6 cm×6 cm至25 cm×25 cm的射野尺寸、100 MU/min至600 MU/min的剂量率以及高达300 cGy的响应线性,未观察到电子束能量变化时响应有变化。与照射后20分钟时的值相比,20 MeV电子束的瞬态信号衰减比6 MeV电子束高约5%。还发现,在200次连续读出中,每次读出时OSL信号的损耗也随电子束的剂量和能量而变化,从6 MeV(在2 Gy和10 Gy时每次读出分别为9%和12%)到20 MeV(在2 Gy和10 Gy时分别为9%和16%)。随着累积剂量从2 Gy到8 Gy以及电子能量从6 MeV到20 MeV,OSL灵敏度在2%至6%的范围内变化,但灵敏度可通过光学退火处理重置。尽管照射后从20分钟到几个月的储存期间衰减可忽略不计、在所需范围内具有可接受的精度和线性以及高重现性使纳米点剂量计对治疗性电子束的剂量测定非常有吸引力,但对于超过2 Gy的剂量下灵敏度的变化以及再利用时电子束能量依赖性、短期衰减和重复读出时的信号损耗应予以注意。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/183d/5370337/7f0530eab5d6/JMP-42-42-g002.jpg

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