Department of Oncology and Nuclear Medicine, University Hospital 'Sestre milosrdnice', Zagreb, Croatia.
Phys Med Biol. 2011 Sep 21;56(18):6065-82. doi: 10.1088/0031-9155/56/18/018. Epub 2011 Aug 26.
A commercial optically stimulated luminescence (OSL) dosimetry system was investigated for in vivo dosimetry in radiation therapy. Dosimetric characteristics of InLight dot dosimeters and a microStar reader (Landauer Inc.) were tested in (60)Co beams. The reading uncertainty of a single dosimeter was 0.6%. The reproducibility of a set of dosimeters after a single irradiation was 1.6%, while in repeated irradiations of the same dosimeters it was found to be 3.5%. When OSL dosimeters were optically bleached between exposures, the reproducibility of repeated measurements improved to 1.0%. Dosimeters were calibrated for the entrance dose measurements and a full set of correction factors was determined. A pilot patient study that followed phantom validation testing included more than 100 measured fields with a mean relative difference of the measured entrance dose from the expected dose of 0.8% and the standard deviation of 2.5%. In conclusion, these results demonstrate that OSL dot dosimeters represent a valid alternative to already established in vivo dosimetry systems.
一种商用的光激励发光（OSL）剂量测定系统被研究用于放射治疗中的体内剂量测定。InLight 点剂量计和 microStar 读取器（Landauer Inc.）的剂量学特性在（60）Co 射束中进行了测试。单个剂量计的读数不确定度为 0.6%。一组剂量计在单次照射后的重复性为 1.6%，而在相同剂量计的重复照射中，发现重复性为 3.5%。当 OSL 剂量计在暴露之间进行光漂白时，重复测量的重复性提高到 1.0%。剂量计被校准用于入口剂量测量，并确定了一整套修正因子。一个跟随体模验证测试的患者初步研究包括了超过 100 个测量场，测量的入口剂量与预期剂量的平均相对差异为 0.8%，标准偏差为 2.5%。总之，这些结果表明 OSL 点剂量计代表了一种已经确立的体内剂量测定系统的有效替代方案。
