Morini Sergio, Ridola Lorenzo, Hassan Cesare, Lorenzetti Roberto, Boggi Roberto, Napoli Massimo, Tomao Silverio, Zullo Angelo
Gastroenterology and Digestive Endoscopy, Nuovo Regina Margherita Hospital, Rome, Italy.
Gastroenterology Unit, 'Sapienza' University of Rome, Polo Pontino Hospital, Latina, Italy.
United European Gastroenterol J. 2017 Feb;5(1):134-138. doi: 10.1177/2050640615627714. Epub 2016 Jul 8.
The association between diverticulosis and colonic neoplastic lesions has been suggested, but data in literature are conflicting. This study aimed to investigate such a relationship in patients participating in a colorectal cancer screening program who underwent high-quality colonoscopy.
Data from consecutive individuals 50-75 years of age with a positive faecal immunological test were considered. Diverticulosis was categorised as present or absent. The prevalence of neoplastic lesions (adenoma, advanced adenoma, and cancer) between individuals with and those without diverticula was compared. A multivariate analysis was performed.
Overall, data from 970 consecutive individuals were evaluated, and diverticulosis was detected in 354 (36.5%) cases. At least one adenoma was detected in 490 (50.5%) people, at least one advanced adenoma in 264 (27.2%), multiple adenoma in 71 (7.3%), whilst a cancer was diagnosed in 48 (4.9%) cases. At univariate analysis, the adenoma detection rate in patients with diverticula was significantly higher than in controls (55.9% vs 47.4%; = 0.011). At multivariate analysis, presence of diverticulosis was an independent risk factor for both adenoma detection rate (OR = 1.58; 95% CI = 1.14-2.18; = 0.006) and advanced adenoma (OR = 1.57; 95% CI = 1.10-2.24; = 0.013), but not for colorectal cancer.
In a colorectal screening setting, the adenoma detection rate was significantly higher in individuals with diverticulosis than in controls.
憩室病与结肠肿瘤性病变之间的关联已被提出，但文献中的数据相互矛盾。本研究旨在调查参与结直肠癌筛查项目且接受高质量结肠镜检查的患者中的这种关系。
考虑来自连续的50 - 75岁粪便免疫检测呈阳性个体的数据。憩室病分为存在或不存在。比较有憩室和无憩室个体之间肿瘤性病变（腺瘤、高级别腺瘤和癌）的患病率。进行多变量分析。
总体而言，评估了970例连续个体的数据，其中354例（36.5%）检测到憩室病。490人（50.5%）检测到至少一个腺瘤，264人（27.2%）检测到至少一个高级别腺瘤，71人（7.3%）检测到多个腺瘤，而48例（4.9%）诊断为癌。单变量分析时，有憩室患者的腺瘤检出率显著高于对照组（55.9%对47.4%；P = 0.011）。多变量分析时，憩室病的存在是腺瘤检出率（OR = 1.58；95%CI = 1.14 - 2.18；P = 0.006）和高级别腺瘤（OR = 1.57；95%CI = 1.10 - 2.24；P = 0.013）的独立危险因素，但不是结直肠癌的独立危险因素。
在结直肠癌筛查环境中，有憩室病个体的腺瘤检出率显著高于对照组。
