使用磷酸三甲酯由二醇合成环状醚。
Cyclic ether synthesis from diols using trimethyl phosphate.
作者信息
Asai Shota, Kato Maho, Monguchi Yasunari, Sajiki Hironao, Sawama Yoshinari
机构信息
Laboratory of Organic Chemistry, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan.
出版信息
Chem Commun (Camb). 2017 Apr 27;53(35):4787-4790. doi: 10.1039/c7cc01514c.
Cyclic ethers have been effectively synthesized via the intramolecular cyclization of diols using trimethyl phosphate and NaH. The present cyclization could proceed at room temperature to produce 5-7 membered cyclic ethers in good to excellent yields. Substrates possessing a chiral secondary hydroxy group were transformed into the corresponding chiral cyclic ethers along with the retention of their stereochemistries.
通过使用磷酸三甲酯和氢化钠使二醇进行分子内环化反应，已有效地合成了环状醚。当前的环化反应可以在室温下进行，以良好至优异的产率生成5至7元环状醚。具有手性仲羟基的底物被转化为相应的手性环状醚，同时其立体化学得以保留。
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