Yao J K, Dyck P J
Psychiatry Service, VA Medical Center, Pittsburgh, PA 15206.
Neurochem Pathol. 1987 Dec;7(3):251-61. doi: 10.1007/BF03160184.
Studying in vitro incorporation of [3H]galactose into biopsied sural endoneurium, we have demonstrated biosynthesis of glucocerebroside and its homologs, lactosylceramide, trihexosylceramide, and tetrahexosylceramide, in normal adult human sural nerve. Such in vitro biosynthesis of oligohexosylceramides is markedly increased in biopsied sural nerve from patients with various types of peripheral neuropathy. Since this altered glycosphingolipid biosynthesis occurs in several diversely caused polyneuropathies, it presumably relates to degenerative or regenerative events characteristic of neuropathy rather than a specific variety of neuropathy.
通过研究[3H]半乳糖在活检腓肠神经内膜中的体外掺入情况，我们已经证实在正常成人腓肠神经中存在葡糖脑苷脂及其同系物乳糖基神经酰胺、三己糖神经酰胺和四己糖神经酰胺的生物合成。在患有各种类型周围神经病的患者的活检腓肠神经中，这种寡糖神经酰胺的体外生物合成显著增加。由于这种糖鞘脂生物合成的改变发生在多种不同病因引起的多发性神经病中，它可能与神经病的退行性或再生性事件有关，而不是与特定类型的神经病有关。
