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糖尿病患者的腓肠神经氧分压

Sural nerve oxygen tension in diabetes.

作者信息

Newrick P G, Wilson A J, Jakubowski J, Boulton A J, Ward J D

出版信息

Br Med J (Clin Res Ed). 1986 Oct 25;293(6554):1053-4. doi: 10.1136/bmj.293.6554.1053.

DOI:10.1136/bmj.293.6554.1053
PMID:3094772
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1341910/
Abstract

Peripheral nerve oxygen tensions were assessed in vivo by using microelectrodes to measure endoneurial oxygen tension in exposed sural nerve. In 11 diabetic patients with chronic sensorimotor neuropathy the mean endoneurial oxygen tension was 39.7 (SD 10.2) mm Hg. In all but one patient compared with none of four non-neuropathic subjects the mean nerve oxygen tensions were below dorsal foot vein values. This unphysiological state may have a role in the aetiology of diabetic neuropathy.

摘要

通过使用微电极测量暴露的腓肠神经的神经内膜氧张力，在体内评估周围神经的氧张力。在11例患有慢性感觉运动性神经病变的糖尿病患者中，神经内膜平均氧张力为39.7（标准差10.2）毫米汞柱。除1例患者外，所有患者的平均神经氧张力均低于4例非神经病变受试者中的任何一人，且低于足背静脉值。这种非生理状态可能在糖尿病神经病变的病因学中起作用。

相似文献

1
Sural nerve oxygen tension in diabetes.糖尿病患者的腓肠神经氧分压
Br Med J (Clin Res Ed). 1986 Oct 25;293(6554):1053-4. doi: 10.1136/bmj.293.6554.1053.
2
Axoplasmic flow in human sural nerve.人腓肠神经中的轴浆流
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3
Increased endoneurial albumin in diabetic polyneuropathy.糖尿病性多发性神经病变中神经内膜白蛋白增加。
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Increased biosynthesis of endoneurial oligohexosylceramides in human peripheral neuropathy.人类周围神经病变中神经内膜寡己糖神经酰胺生物合成增加。
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Proc Natl Acad Sci U S A. 1988 Jul;85(13):4879-83. doi: 10.1073/pnas.85.13.4879.

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本文引用的文献

1
Diabetic neuropathy: a clinical and histological study on the significance of vascular affections.糖尿病性神经病变：关于血管病变意义的临床与组织学研究
Acta Med Scand Suppl. 1959;345:1-97.
2
Human diabetic endoneurial sorbitol, fructose, and myo-inositol related to sural nerve morphometry.与腓肠神经形态测量学相关的人类糖尿病性神经内膜山梨醇、果糖和肌醇。
Ann Neurol. 1980 Dec;8(6):590-6. doi: 10.1002/ana.410080608.
3
Venous distension in the diabetic neuropathic foot (physical sign of arteriovenous shunting).糖尿病神经病变足的静脉扩张（动静脉分流的体征）。
J R Soc Med. 1983 Dec;76(12):1011-4. doi: 10.1177/014107688307601206.
4
Prevention of some electrophysiologic and biochemical abnormalities with oxygen supplementation in experimental diabetic neuropathy.实验性糖尿病神经病变中补充氧气对某些电生理和生化异常的预防作用
Proc Natl Acad Sci U S A. 1984 Nov;81(21):6894-8. doi: 10.1073/pnas.81.21.6894.
5
Endoneurial blood flow and oxygen tension in the sciatic nerves of rats with experimental diabetic neuropathy.实验性糖尿病性神经病变大鼠坐骨神经的神经内膜血流及氧张力
Brain. 1984 Sep;107 ( Pt 3):935-50. doi: 10.1093/brain/107.3.935.
6
Small vessel disease in progressive diabetic neuropathy associated with good metabolic control.与良好代谢控制相关的进行性糖尿病神经病变中的小血管疾病
J Clin Pathol. 1985 Sep;38(9):1030-8. doi: 10.1136/jcp.38.9.1030.
7
Capillary number and percentage closed in human diabetic sural nerve.人类糖尿病腓肠神经中的毛细血管数量及闭合百分比。
Proc Natl Acad Sci U S A. 1985 Apr;82(8):2513-7. doi: 10.1073/pnas.82.8.2513.
8
Glucose-induced alterations in nerve metabolism: current perspective on the pathogenesis of diabetic neuropathy and future directions for research and therapy.
Diabetes Care. 1985 May-Jun;8(3):290-9. doi: 10.2337/diacare.8.3.290.