Department of Chemistry, Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Tianjin University, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) , Tianjin 300072, P. R. China.
Org Lett. 2017 Apr 21;19(8):2162-2165. doi: 10.1021/acs.orglett.7b00797. Epub 2017 Apr 13.
An organocatalytic asymmetric decarboxylative amination reaction of β-keto acids is described. Under mild reaction conditions, a series of chiral α-amino ketones were obtained in good to high yields (up to 99%) and enantioselectivities (up to 95% ee). A chiral 1,2-amino alcohol was synthesized from the corresponding decarboxylative amination product in several steps without loss of enantioselectivity.
描述了一种β-酮酸的有机催化不对称脱羧胺化反应。在温和的反应条件下，一系列手性α-氨基酮以良好到高的收率（高达 99%）和对映选择性（高达 95%ee）得到。通过几步反应，从相应的脱羧胺化产物中合成了手性 1,2-氨基醇，对映选择性没有损失。
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