不对称有机催化脱羧 Mannich 反应使用β-酮酸：手性β-氨基酮合成的新方法。
Asymmetric organocatalytic decarboxylative Mannich reaction using β-keto acids: A new protocol for the synthesis of chiral β-amino ketones.
机构信息
Department of Chemistry & Medicinal Chemistry Program, Life Sciences Institute, National University of Singapore, 3 Science Drive 3, Republic of Singapore, 117543.
出版信息
Beilstein J Org Chem. 2012;8:1279-83. doi: 10.3762/bjoc.8.144. Epub 2012 Aug 13.
Abstract
The first decarboxylative Mannich reaction employing β-keto acids, catalyzed by cinchonine-derived bifunctional thiourea catalyst has been described. The desired β-amino ketones were obtained in excellent yields and with moderate to good enantioselectivities.
摘要
首次报道了使用β-酮酸、金鸡纳生物碱衍生的双功能硫脲催化剂催化的脱羧 Mannich 反应。以优异的产率和中等至良好的对映选择性得到了所需的β-氨基酮。
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