4-烷基异喹啉-1,3(2,4)-二酮衍生物的对映选择性胺化反应
Enantioselective amination of 4-alkylisoquinoline-1,3(2,4)-dione derivatives.
作者信息
Cheng Cheng, Li Ying-Xian, Jia Xue-Min, Zhang Ji-Quan, Zhao Yong-Long, Feng Wei, Tang Lei, Yang Yuan-Yong
机构信息
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, School of Pharmacy, Guizhou Medical University Guiyang 550004 China
BGI-Shenzhen Building 11, Beishan Industrial Zone, Yantian Shenzhen 518083 China.
出版信息
RSC Adv. 2020 Nov 25;10(70):42912-42915. doi: 10.1039/d0ra07806a. eCollection 2020 Nov 23.
A mild and efficient enantioselective amination of 4-alkylisoquinoline-1,3(2,4)-dione derivatives was established, which is compatible with a broad range of substrates and delivers the final products in excellent yields (up to 99%) and ee values (up to 99%) with low catalyst loading (down to 1 mol%). The synthetic potential of this methodology was also demonstrated in the gram scale level.
建立了一种温和且高效的4-烷基异喹啉-1,3(2,4)-二酮衍生物的对映选择性胺化反应，该反应与多种底物兼容，能以低催化剂负载量（低至1 mol%）、优异的产率（高达99%）和对映体过量值（高达99%）得到最终产物。该方法的合成潜力也在克级规模上得到了证明。
Zotero 插件