Granic Antoneta, Hill Tom R, Davies Karen, Jagger Carol, Adamson Ashley, Siervo Mario, Kirkwood Thomas B L, Mathers John C, Sayer Avan A
Institute of Neuroscience, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
NIHR Newcastle Biomedical Research Centre, Newcastle University and Newcastle upon Tyne NHS Foundation Trust, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK.
Nutrients. 2017 Apr 13;9(4):379. doi: 10.3390/nu9040379.
Mixed reports exist about the role of 25-hydroxyvitamin D (25(OH)D) in muscle ageing and there are few prospective studies involving the very old (aged ≥ 85) who are at highest risk of low 25(OH)D, loss of muscle mass and strength, and physical performance decline. In the Newcastle 85+ Study ( = 845), we aimed to determine the association between 25(OH)D season-specific quartiles (hereafter SQ1-SQ4), grip strength (GS) and physical performance decline (Timed Up-and-Go Test, TUG) over 5 years using mixed models. In the time-only models with linear and quadratic slopes, SQ1 and SQ4 of 25(OH)D were associated with weaker GS initially in men (SQ1: β (SE) = -2.56 (0.96); SQ4: -2.16 (1.06)) and women (SQ1: -1.10 (0.52); SQ4: -1.28 (0.50)) (all ≤ 0.04). In the fully adjusted models, only men in SQ1 had a significant annual decline in GS of 1.41 kg which accelerated over time (-0.40 (0.1)), (both ≤ 0.003) compared with those in combined middle quartiles. Only women in SQ1 and SQ4 of 25(OH)D had worse TUG times initially, but the rate of TUG decline was not affected. Low baseline 25(OH)D may contribute to muscle strength decline in the very old and particularly in men.
关于25-羟基维生素D（25(OH)D）在肌肉衰老中的作用，存在各种不同的报道。很少有前瞻性研究涉及年龄非常大（≥85岁）的人群，他们发生25(OH)D水平低、肌肉量和力量丧失以及身体机能下降的风险最高。在纽卡斯尔85岁以上研究（n = 845）中，我们旨在使用混合模型确定25(OH)D季节特异性四分位数（以下简称SQ1 - SQ4）、握力（GS）和5年期间身体机能下降（定时起立行走测试，TUG）之间的关联。在具有线性和二次斜率的仅时间模型中，25(OH)D的SQ1和SQ4最初与男性（SQ1：β（标准误）=-2.56（0.96）；SQ4：-2.16（1.06））和女性（SQ1：-1.10（0.52）；SQ四：-1.28（0.50））较弱的握力相关（所有P≤0.04）。在完全调整模型中，与处于中间四分位数组合的人群相比，仅处于SQ1的男性握力每年显著下降1.41千克，且随时间加速下降（-0.40（0.1））（两者P≤0.003）。仅25(OH)D处于SQ1和SQ4的女性最初TUG时间较差，但TUG下降速率未受影响。低基线25(OH)D可能导致年龄非常大的人群尤其是男性的肌肉力量下降。
