Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA.
Bone. 2023 Nov;176:116867. doi: 10.1016/j.bone.2023.116867. Epub 2023 Aug 5.
Osteoporosis and sarcopenia are prevalent in older adults. Trabecular bone score (TBS) is a novel method to evaluate bone microarchitecture, whereas grip strength and gait speed are simple methods to assess muscle strength and function. Few studies have linked the relationship between vitamin D levels (25OHD) with TBS, grip strength, and gait speed in healthy community dwelling adults. We sought to investigate this relationship in older women with osteoporosis and multiple comorbid conditions residing in long-term care (LTC) facilities.
We analyzed baseline 25OHD, spine TBS, grip strength, and gait speed in 246 women with osteoporosis who were residents of LTC and enrolled in a randomized controlled clinical trial.
On average, participants were 81.6 years old and had a BMI of 26.8 kg/m. The correlation (r) of 25OHD with spine TBS, grip strength, and gait speed were (r = 0.15; p = 0.0208), (r = - 0.05; p = 0.4686), and (r = 0.19; p = 0.0041), respectively. Each 5 ng/dl increase in 25OHD was associated with an increase of 0.006 in spine TBS and 0.014 m/s in gait speed. After adjusting for covariates, each 5 ng/dl increase in 25OHD was associated with an increase of 0.004 in spine TBS (p = 0.0599) and 0.012 m/s in gait speed (p = 0.0144).
In older women residing in LTC facilities, 25OHD was associated with spine TBS and gait speed. The strengths of the associations suggest there may be other factors with a more prominent role in bone microarchitecture, muscle strength, and physical function in this population.
Our study found in older women who are residents of long-term care facilities, vitamin D level is associated with bone microarchitecture and mobility performance.
骨质疏松症和肌肉减少症在老年人中很常见。骨小梁评分（TBS）是一种评估骨微结构的新方法，而握力和步速是评估肌肉力量和功能的简单方法。很少有研究将维生素 D 水平（25OHD）与 TBS、握力和步速联系起来，以评估健康的社区居住成年人。我们旨在调查居住在长期护理（LTC）设施中的患有骨质疏松症和多种合并症的老年女性中这种关系。
我们分析了 246 名患有骨质疏松症的 LTC 居民的基线 25OHD、脊柱 TBS、握力和步速。
平均而言，参与者年龄为 81.6 岁，BMI 为 26.8kg/m²。25OHD 与脊柱 TBS、握力和步速的相关性（r）分别为（r=0.15；p=0.0208）、（r=-0.05；p=0.4686）和（r=0.19；p=0.0041）。25OHD 每增加 5ng/dl，脊柱 TBS 增加 0.006，步速增加 0.014m/s。调整协变量后，25OHD 每增加 5ng/dl，脊柱 TBS 增加 0.004（p=0.0599），步速增加 0.012m/s（p=0.0144）。
在居住在 LTC 设施中的老年女性中，25OHD 与脊柱 TBS 和步速相关。这些关联的强度表明，在该人群中，可能还有其他因素对骨微结构、肌肉力量和身体功能有更显著的作用。
我们的研究发现，在居住于长期护理机构的老年女性中，维生素 D 水平与骨微结构和活动能力相关。
