Takagi Dermatological Clinic, Obihiro, Japan.
Department of Dermatology, Housui General Medical Clinic, Sapporo, Japan.
J Dermatol. 2017 Sep;44(9):1024-1026. doi: 10.1111/1346-8138.13859. Epub 2017 Apr 13.
Topical and systemic agents have dramatically improved the treatment efficacy of psoriasis. Few reports, however, exist describing the economic burden in Japanese psoriatic patients. The aim of the study was to evaluate the total costs as well as cost versus efficacy of topical and systemic treatments of psoriatic patients under the Japanese health insurance system. The retrospective study was performed from the database of our clinic, which is located in Hokkaido Prefecture. Cost and effectiveness of psoriatic patients were evaluated during the 12-month period from April 2015 to March 2016. Data were collected and calculated for the total cost per year, treatment efficacy and cost versus efficacy. The mean total cost of topical corticosteroid treatment was ¥18 184/year and was lowest among the treatments. The systemic treatment with biologics was most expensive and the costs were over ¥400 000/year. Among the topical treatments, calcipotriol/betamethasone dipropionate was most expensive (¥34 693/year). However, cost versus efficacy was not significantly different from that of topical corticosteroid treatments. The cost of secukinumab was highest among all the treatments (¥631 600/year). However, treatment day per cost was lowest of all the psoriasis treatments. Biologics showed the highest cost than topical or systemic treatments. However, they showed most marked efficacy in terms of improving the psoriatic skin lesions.
局部和全身治疗药物显著改善了银屑病的治疗效果。然而，鲜有关于日本银屑病患者经济负担的报道。本研究旨在评估日本医保制度下银屑病患者局部和全身治疗的总费用及成本效益比。本回顾性研究的数据来自我们位于北海道的诊所数据库。2015 年 4 月至 2016 年 3 月的 12 个月期间，评估了银屑病患者的成本和疗效。收集并计算了每年的总费用、治疗效果和成本效益比。局部皮质类固醇治疗的平均总费用为 18184 日元/年，在所有治疗方法中最低。生物制剂的全身治疗费用最高，超过 400000 日元/年。在局部治疗中，钙泊三醇/倍他米松二丙酸酯费用最高（34693 日元/年）。然而，成本效益比与皮质类固醇治疗无显著差异。司库奇尤单抗的费用在所有治疗中最高（631600 日元/年）。然而，其治疗成本/天在所有银屑病治疗中最低。生物制剂的费用高于局部或全身治疗，但在改善银屑病皮损方面效果最显著。
