Novartis Pharma K.K., Tokyo, Japan.
Hiroshima University, Hiroshima, Japan.
J Dermatol. 2018 Aug;45(8):963-970. doi: 10.1111/1346-8138.14502. Epub 2018 Jun 13.
Little attention has been given to the burden of chronic urticaria (CU) in Japan compared with other skin diseases, such as atopic dermatitis (AD) and psoriasis. The primary objective of the RELEASE study was to evaluate the real-life quality-of-life impairment in CU patients in Japan. Data were collected from 1443 urticaria, 1668 AD and 435 psoriatic patients; 552 urticaria patients who presented urticaria symptoms for over 6 weeks were defined as CU. The mean Dermatology Life Quality Index (DLQI) total score was 4.8, 6.1 and 4.8 in CU, AD and psoriatic patients, respectively. Disease control of urticaria evaluated by the Urticaria Control Test (UCT) and DLQI exhibited a strong correlation with a Spearman's rank correlation coefficient of -0.7158. CU and AD patients had relatively higher scores in all Work Productivity and Activity Impairment - General Health subscales except for absenteeism. At the time of the survey, approximately 64% of CU patients reported UCT scores of <12 and demonstrated higher work productivity loss and activity impairment versus patients with UCT scores of ≥12. Patients with lower UCT scores also displayed a higher percentage of dissatisfaction with their health state and the treatment they received. Approximately 85% of patients with CU had visited dermatology clinics, and less than 20% had visited hospital, indicating existence of a highly burdened population outside specialized centers. These results highlight the unmet medical needs of CU patients, suggesting the need to increase awareness of CU burden among both physicians and patients and to pursue improved real-life patient care.
与特应性皮炎（AD）和银屑病等其他皮肤病相比，日本对慢性荨麻疹（CU）的负担关注较少。RELEASE 研究的主要目的是评估日本 CU 患者的真实生活质量受损情况。从 1443 例荨麻疹、1668 例 AD 和 435 例银屑病患者中收集数据；552 例出现荨麻疹症状超过 6 周的荨麻疹患者被定义为 CU。CU、AD 和银屑病患者的皮肤病生活质量指数（DLQI）总分分别为 4.8、6.1 和 4.8。荨麻疹控制测试（UCT）和 DLQI 评估的荨麻疹疾病控制与 Spearman 秩相关系数 -0.7158 具有很强的相关性。CU 和 AD 患者在所有工作效率和活动障碍-一般健康子量表中的得分相对较高，除了旷工。在调查时，大约 64%的 CU 患者报告 UCT 评分<12，与 UCT 评分≥12 的患者相比，工作效率损失和活动障碍更大。UCT 评分较低的患者也对自己的健康状况和所接受的治疗更不满意。大约 85%的 CU 患者曾就诊于皮肤科诊所，不到 20%的患者曾就诊于医院，这表明在专门中心之外存在负担沉重的人群。这些结果突出了 CU 患者未满足的医疗需求，表明需要提高医生和患者对 CU 负担的认识，并寻求改善现实生活中的患者护理。
