弥散加权和磁化传递成像在睾丸生精功能评估中的应用：初步结果。

Diffusion-Weighted and Magnetization Transfer Imaging in Testicular Spermatogenic Function Evaluation: Preliminary Results.

机构信息

Department of Radiology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China.

Ultrosounic Department, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China.

出版信息

J Magn Reson Imaging. 2018 Jan;47(1):186-190. doi: 10.1002/jmri.25732. Epub 2017 Apr 13.

DOI:10.1002/jmri.25732

PMID:28407330

Abstract

PURPOSE

To assess the use of functional magnetic resonance imaging (MRI), including diffusion-weighted MRI (DWI) and magnetization transfer MRI (MTI) in evaluating male infertility.

MATERIALS AND METHODS

Sixteen men with testicular spermatogenesis hypofunction confirmed by percutaneous testis biopsy and 31 volunteers (control group B, age range: 20-40 years) with normal semen analysis including younger (By, n = 15, age range: 20-30 years) and older (Bo, n = 16, age range: 31-40 years) men underwent pelvic 3T MRI, including DWI and MTI. Apparent diffusion coefficient (ADC) and magnetization transfer ratio (MTR) were compared.

RESULTS

The ADCs in 32 testes of 16 patients (0.497 ± 0.037 × 10 mm /s) were significantly (P < 0.001) higher than that of control group B (0.460 ± 0.031 × 10 mm /s), group By (0.453 ± 0.018 × 10 mm /s), and group Bo (0.461 ± 0.034 × 10 mm /s), whereas the MTRs were significantly lower than that of group B (16.14 ± 4.20), group By (17.88 ± 2.00), and group Bo (15.09 ± 4.28) (P < 0.001).

CONCLUSION

Functional MRI, including DWI and MTI, appears promising for evaluating male infertility with higher ADC and lower MTR in testicular spermatogenesis hypofunction.

LEVEL OF EVIDENCE

2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;47:186-190.

摘要

目的

评估功能磁共振成像（MRI），包括扩散加权 MRI（DWI）和磁化传递 MRI（MTI）在评估男性不育症中的应用。

材料与方法

16 名经经皮睾丸活检证实的睾丸生精功能低下的男性患者（研究组 A）和 31 名精液分析正常的志愿者（对照组 B，年龄范围：20-40 岁），包括年龄较小的（By，n=15，年龄范围：20-30 岁）和年龄较大的（Bo，n=16，年龄范围：31-40 岁），均接受盆腔 3T MRI 检查，包括 DWI 和 MTI。比较表观扩散系数（ADC）和磁化转移率（MTR）。

结果

16 例患者的 32 个睾丸 ADC 值（0.497±0.037×10mm/s）明显（P<0.001）高于对照组 B（0.460±0.031×10mm/s）、By 组（0.453±0.018×10mm/s）和 Bo 组（0.461±0.034×10mm/s），而 MTR 值明显低于对照组 B（16.14±4.20）、By 组（17.88±2.00）和 Bo 组（15.09±4.28）（P<0.001）。