Institute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA BRAIN Institute I, Jülich Research Centre, Jülich, Germany; Bernstein Center Freiburg, Albert-Ludwig University of Freiburg, Germany; Faculty of Biology, Albert-Ludwig University of Freiburg, Freiburg im Breisgau, Germany; Institute of Adaptive and Neural Computation, School of Informatics, University of Edinburgh, UK.
School of Computer and Communication Sciences and School of Life Sciences, Brain Mind Institute, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Curr Opin Neurobiol. 2017 Apr;43:156-165. doi: 10.1016/j.conb.2017.02.007. Epub 2017 Apr 10.
Neocortical circuits, as large heterogeneous recurrent networks, can potentially operate and process signals at multiple timescales, but appear to be differentially tuned to operate within certain temporal receptive windows. The modular and hierarchical organization of this selectivity mirrors anatomical and physiological relations throughout the cortex and is likely determined by the regional electrochemical composition. Being consistently patterned and actively regulated, the expression of molecules involved in synaptic transmission constitutes the most significant source of laminar and regional variability. Due to their complex kinetics and adaptability, synapses form a natural primary candidate underlying this regional temporal selectivity. The ability of cortical networks to reflect the temporal structure of the sensory environment can thus be regulated by evolutionary and experience-dependent processes.
新皮层回路作为大型异质的递归网络，能够在多个时间尺度上运行和处理信号，但似乎针对特定的时间感受窗进行了差异化的调谐。这种选择性的模块化和层次化组织反映了整个皮层的解剖学和生理学关系，并且可能由区域电化学组成决定。涉及突触传递的分子的表达是分层和区域变异性的最重要来源，它们具有一致性的模式和主动调节。由于其复杂的动力学和适应性，突触形成了区域时间选择性的天然主要候选者。因此，皮质网络反映感觉环境时间结构的能力可以通过进化和经验依赖的过程来调节。
