Dogan S K, Boyacioglu S, Kodal M, Gokce O, Ozkoc G
Department of Chemical Engineering, Kocaeli University, Kocaeli 41380, Turkey.
Department of Polymer Science and Technology, Kocaeli University, Kocaeli 41380, Turkey.
J Mech Behav Biomed Mater. 2017 Jul;71:349-361. doi: 10.1016/j.jmbbm.2017.04.001. Epub 2017 Apr 6.
Poly(lactic acid) (PLA)/thermoplastic polyurethane (TPU) blends were melt-mixed and compatibilized to investigate their biocompatibility, biodegradability and thermally induced shape memory properties. The blend compositions were PLA/TPU: 80/20 (20TPU) and PLA/TPU: 50/50 (50TPU). 1,4-phenylene diisocyanate (PDI) was used in order to compatibilize the components reactively. The PDI composition was 0.5, 1, 3% by weight. Biodegradability was assessed by enzymatic degradation tests. Biocompatibility was investigated through in-vitro cell-culture experiments. Shape memory tests exhibited that 20TPU blends have higher recovery ratio than that of 50TPU blends. It was observed that the shape recovery ratio was enhanced by the addition of PDI. The highest shape recovery ratio was obtained at 3%PDI in 20TPU blends. Enzymatic biodegradability tests showed that the increasing TPU content decreased the biodegradability of the blends. It was found that compatibilization slowed down the enzymatic degradation of PLA/TPU blends. In-vitro cell-culture experiments indicated that all blends were biocompatible, and no evidence of cytotoxicity was observed.
聚乳酸（PLA）/热塑性聚氨酯（TPU）共混物经熔融混合和增容处理，以研究其生物相容性、生物降解性和热致形状记忆性能。共混物组成分别为PLA/TPU：80/20（20TPU）和PLA/TPU：50/50（50TPU）。使用1,4 - 亚苯基二异氰酸酯（PDI）对各组分进行反应性增容。PDI的组成按重量计分别为0.5%、1%、3%。通过酶降解试验评估生物降解性。通过体外细胞培养实验研究生物相容性。形状记忆测试表明，20TPU共混物的回复率高于50TPU共混物。观察到添加PDI可提高形状回复率。在20TPU共混物中，3%PDI时获得最高形状回复率。酶促生物降解试验表明，TPU含量增加会降低共混物的生物降解性。发现增容作用减缓了PLA/TPU共混物的酶促降解。体外细胞培养实验表明，所有共混物均具有生物相容性，未观察到细胞毒性迹象。
