Ajili Shadi Hassan, Ebrahimi Nadereh Golshan, Soleimani Masoud
Department of Polymer Engineering, Faculty of Engineering, Tarbiat Modares University, Tehran, Iran.
Acta Biomater. 2009 Jun;5(5):1519-30. doi: 10.1016/j.actbio.2008.12.014. Epub 2009 Jan 3.
Shape memory materials have been proposed for cardiovascular stents due to their self-expansion ability. The most ideal way to anchor a stent is using self-expansion in the range of body temperature. This work, for the first time, reports the use of polyurethane/polycaprolactone (PU/PCL) blend as a proposed material for shape memory stents. Polyurethane copolymer based on poly(epsilon-caprolactone) diol was melt blended with PCL in four different ratios of 20, 30, 40 and 50 wt.% and their shape memory behaviors were examined. All blends except for PU/PCL(80/20) showed shape memory effects with recovery temperatures of around the melting temperature of PCL in the blends. The melting behavior of the PCL in the blends is strongly influenced by composition. Changing the composition of the blend system and crystallization conditions adjusted shape recovery to the range of body temperature for PU/PCL(70/30) blend. The in vitro biocompatibility of PU/PCL(70/30) blend was evaluated in this study using human bone marrow mesenchymal stem cells (hBMSCs). The adhesion, morphology and mitochondrial function were analyzed in order to investigate the cell viability during cell culture on PU/PCL(70/30) blend surface. The results showed that the blend supported cell adhesion and proliferation, which indicated good biocompatibility. Our results suggested that this blend might be a potential material as a stent implant.
由于形状记忆材料具有自膨胀能力，已被提议用于心血管支架。固定支架最理想的方法是在体温范围内实现自膨胀。本研究首次报道了使用聚氨酯/聚己内酯（PU/PCL）共混物作为形状记忆支架的候选材料。基于聚（ε-己内酯）二醇的聚氨酯共聚物与PCL以20、30、40和50 wt.% 四种不同比例进行熔融共混，并对其形状记忆行为进行了研究。除PU/PCL(80/20) 外，所有共混物均表现出形状记忆效应，其恢复温度约为共混物中PCL的熔点。共混物中PCL的熔融行为受组成的强烈影响。通过改变共混体系的组成和结晶条件，将PU/PCL(70/30) 共混物的形状恢复温度调整到了体温范围内。本研究使用人骨髓间充质干细胞（hBMSCs）评估了PU/PCL(70/30) 共混物的体外生物相容性。分析了细胞的粘附、形态和线粒体功能，以研究细胞在PU/PCL(70/30) 共混物表面培养期间的活力。结果表明，该共混物支持细胞粘附和增殖，表明其具有良好的生物相容性。我们的结果表明，这种共混物可能是一种潜在的支架植入材料。
