Shi Guang-Jiang, Li Zhi-Mei, Zheng Jie, Chen Jian, Han Xiao-Xu, Wu Jing, Li Guang-Yong, Chang Qing, Li Yu-Xiang, Yu Jian-Qiang
Department of Pharmacology, Ningxia Medical University, Yinchuan, 750004, China; Guolong Hospital, Yinchuan, 750000, China.
Department of Pharmacology, Ningxia Medical University, Yinchuan, 750004, China.
Biomed Pharmacother. 2017 Jun;90:562-574. doi: 10.1016/j.biopha.2017.03.074. Epub 2017 Apr 10.
Diabetes mellitus (DM) is a major health problem that affects patients' quality of life quality throughout the world due to its many complications. Reproductive dysfunction is one of the major secondary complications in both diabetic animals and human beings. Furthermore, DM has recently broken the age barrier and has been heavily diagnosed in children and young persons of reproductive age. In the past few years, many studies on DM in male reproductive functions in both diabetic men and experimental diabetic animals have been published. It is recognized that sustained hyperglycemia, which impairs reproductive function in diabetic men, is at risk of developing. DM harmfully affects male reproductive functions in multiple areas; these may include spermatogenesis, sperm maturation, fertility capability, penile erection, and ejaculation. Traditional medicine and folklore worldwide have used numerous medicinal plants to manage the diabetic reproductive dysfunction because bioactive phyto-constituents are affluent in many places. Unfortunately, the exact reasons for diabetic male reproductive dysfunction are not completely understood and currently there are no treatments in reproductive medicine specifically for such lesions. The aim of this review is to summarize current research findings of DM on reproductive functions, to elaborate the underlying mechanisms related to these diseases via in vivo and in vitro studies, and to describe the ameliorative effects of medicinal plants or their products. The review findings provide a systematic understanding of DM on the reproductive functions and lay the theoretical foundation for developing the direction of reproductive medicine.
糖尿病（DM）是一个重大的健康问题，由于其诸多并发症，影响着全世界患者的生活质量。生殖功能障碍是糖尿病动物和人类主要的继发性并发症之一。此外，糖尿病最近已突破年龄界限，在育龄儿童和年轻人中被大量诊断出来。在过去几年里，已经发表了许多关于糖尿病男性和实验性糖尿病动物的男性生殖功能的研究。人们认识到，持续高血糖会损害糖尿病男性的生殖功能，存在发病风险。糖尿病在多个方面对男性生殖功能产生有害影响；这些方面可能包括精子发生、精子成熟、生育能力、阴茎勃起和射精。世界各地的传统医学和民间传说使用了许多药用植物来治疗糖尿病性生殖功能障碍，因为许多地方都富含生物活性植物成分。不幸的是，糖尿病男性生殖功能障碍的确切原因尚未完全了解，目前生殖医学中尚无专门针对此类病变的治疗方法。本综述的目的是总结糖尿病对生殖功能的当前研究结果，通过体内和体外研究阐述与这些疾病相关的潜在机制，并描述药用植物或其产品的改善作用。综述结果为糖尿病对生殖功能的影响提供了系统的认识，并为生殖医学发展方向奠定了理论基础。
